The presented method has the potential to find place in a clinical setting as well as to be applied in vivo in the near future. Graphic composition of SHG and FLIM images representing normal arterial wall and plaque depositions. Atherosclerosis is among the most widespread cardiovascular diseases and its early diagnosis is crucial for avoiding life threatening consequences. Non-linear microscopy can diagnose tissues and atherosclerosis in a label-free modality, opening the way for a clinical use of these optical techniques. Combined SHG-FLIM microscopy is demonstrated to be extremely powerful for diagnosing and characterizing atherosclerosis.
Non-linear imaging and characterization of atherosclerotic arterial tissue using combined SHG and FLIM microscopy / Cicchi, Riccardo; Baria, Enrico; Matthäus, Christian; Lange, Marta; Lattermann, Annika; Brehm, Bernhard R.; Popp, Jürgen; Pavone, Francesco Saverio. - In: JOURNAL OF BIOPHOTONICS. - ISSN 1864-063X. - STAMPA. - 8:(2015), pp. 347-356. [10.1002/jbio.201400142]
Non-linear imaging and characterization of atherosclerotic arterial tissue using combined SHG and FLIM microscopy
CICCHI, RICCARDO;BARIA, ENRICO;PAVONE, FRANCESCO SAVERIO
2015
Abstract
The presented method has the potential to find place in a clinical setting as well as to be applied in vivo in the near future. Graphic composition of SHG and FLIM images representing normal arterial wall and plaque depositions. Atherosclerosis is among the most widespread cardiovascular diseases and its early diagnosis is crucial for avoiding life threatening consequences. Non-linear microscopy can diagnose tissues and atherosclerosis in a label-free modality, opening the way for a clinical use of these optical techniques. Combined SHG-FLIM microscopy is demonstrated to be extremely powerful for diagnosing and characterizing atherosclerosis.
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