DNA methylation is an epigenetic repressor mark for transcription dynamically regulated in neurons. We analyzed visual experience regulation of DNA methylation in mice and its involvement in ocular dominance plasticity of the developing visual cortex. Monocular deprivation modulated the expression of factors controlling DNA methylation and exerted opposite effects on DNA methylation and hydroxymethylation in specific plasticity genes. Inhibition of DNA methyltrasferase (DNMT) blocked molecular and functional effects of monocular deprivation, partially reversing the monocular deprivation transcriptional program. © 2015 Nature America, Inc.
Experience-dependent DNA methylation regulates plasticity in the developing visual cortex / Tognini, Paola; Napoli, Debora; Tola, Jonida; Silingardi, Davide; Della Ragione, Floriana; D'Esposito, Maurizio; Pizzorusso, Tommaso. - In: NATURE NEUROSCIENCE. - ISSN 1097-6256. - STAMPA. - 18:(2015), pp. 956-958. [10.1038/nn.4026]
Experience-dependent DNA methylation regulates plasticity in the developing visual cortex
PIZZORUSSO, TOMMASO
2015
Abstract
DNA methylation is an epigenetic repressor mark for transcription dynamically regulated in neurons. We analyzed visual experience regulation of DNA methylation in mice and its involvement in ocular dominance plasticity of the developing visual cortex. Monocular deprivation modulated the expression of factors controlling DNA methylation and exerted opposite effects on DNA methylation and hydroxymethylation in specific plasticity genes. Inhibition of DNA methyltrasferase (DNMT) blocked molecular and functional effects of monocular deprivation, partially reversing the monocular deprivation transcriptional program. © 2015 Nature America, Inc.
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