A d-proline peptidomimetic targeting MMP-2 and MMP-9, being involved during tumor cell invasion and angiogenesis, was identified from a pool of compounds following enzyme inhibition kinetics and zymography, clearly highlighting the invasion inhibitory activity and capacity of blocking capillary network formation in vivo. © 2015 The Royal Society of Chemistry.
A study of a d-proline peptidomimetic inhibitor of melanoma and endothelial cell invasion through activity towards MMP-2 and MMP-9 / Bianchini, Francesca; Calugi, Chiara; Ruzzolini, Jessica; Menchi, Gloria; Calorini, Lido; Guarna, Antonio; Trabocchi, Andrea. - In: MEDCHEMCOMM. - ISSN 2040-2503. - STAMPA. - 6:(2015), pp. 277-282. [10.1039/c4md00287c]
A study of a d-proline peptidomimetic inhibitor of melanoma and endothelial cell invasion through activity towards MMP-2 and MMP-9
BIANCHINI, FRANCESCA;CALUGI, CHIARA;Ruzzolini, Jessica;MENCHI, GLORIA;CALORINI, LIDO;GUARNA, ANTONIO;TRABOCCHI, ANDREA
2015
Abstract
A d-proline peptidomimetic targeting MMP-2 and MMP-9, being involved during tumor cell invasion and angiogenesis, was identified from a pool of compounds following enzyme inhibition kinetics and zymography, clearly highlighting the invasion inhibitory activity and capacity of blocking capillary network formation in vivo. © 2015 The Royal Society of Chemistry.I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.