Sarcopenia is an age-related muscle condition which is frequently a precursor of frailty, mobility disability and premature death. It has a high prevalence in older populations and presents a considerable social and economic burden. Potential treatments are under development but, as yet, no guidelines support regulatory studies for new drugs to manage sarcopenia. The objective of this position paper is therefore to suggest a set of potential endpoints and target population definitions to stimulate debate and progress within the medico-scientific and regulatory communities.
Recommendations for the conduct of clinical trials for drugs to treat or prevent sarcopenia / Reginster, Jy; Cooper, C; Rizzoli, R; Kanis, Ja; Appelboom, G; Bautmans, I; Bischoff-Ferrari, Ha; Boers, M; Brandi, Ml; Bruyère, O; Cherubini, A; Flamion, B; Fielding, Ra; Gasparik, Ai; Van Loon, L; Mccloskey, E; Mitlak, Bh; Pilotto, A; Reiter-Niesert, S; Rolland, Y; Tsouderos, Y; Visser, M; Cruz-Jentoft, Aj.. - In: AGING CLINICAL AND EXPERIMENTAL RESEARCH. - ISSN 1720-8319. - ELETTRONICO. - 30:(2015), pp. 1-1.
Recommendations for the conduct of clinical trials for drugs to treat or prevent sarcopenia.
BRANDI, MARIA LUISA;
2015
Abstract
Sarcopenia is an age-related muscle condition which is frequently a precursor of frailty, mobility disability and premature death. It has a high prevalence in older populations and presents a considerable social and economic burden. Potential treatments are under development but, as yet, no guidelines support regulatory studies for new drugs to manage sarcopenia. The objective of this position paper is therefore to suggest a set of potential endpoints and target population definitions to stimulate debate and progress within the medico-scientific and regulatory communities.File | Dimensione | Formato | |
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