The presence of sequence variants in miRNA genes may influence their processing, expression and binding to target mRNAs. Since single miRNA can have a large number of potential mRNA targets, even minor variations in its expression can have influences on hundreds of putative mRNAs.
Genetic variants in miR-146a, miR-149, miR-196a2, miR-499 and their influence on relative expression in lung cancers / Vinci, Serena; Gelmini, Stefania; Pratesi, Nicola; Conti, Simona; Malentacchi, Francesca; Simi, Lisa; Pazzagli, Mario; Orlando, Claudio. - In: CLINICAL CHEMISTRY AND LABORATORY MEDICINE. - ISSN 1437-4331. - ELETTRONICO. - 49:(2011), pp. 2073-2080. [10.1515/CCLM.2011.708]
Genetic variants in miR-146a, miR-149, miR-196a2, miR-499 and their influence on relative expression in lung cancers
VINCI, SERENA;GELMINI, STEFANIA;PRATESI, NICOLA;CONTI, SIMONA;MALENTACCHI, FRANCESCA;SIMI, LISA;PAZZAGLI, MARIO;ORLANDO, CLAUDIO
2011
Abstract
The presence of sequence variants in miRNA genes may influence their processing, expression and binding to target mRNAs. Since single miRNA can have a large number of potential mRNA targets, even minor variations in its expression can have influences on hundreds of putative mRNAs.
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