Sarcopenia represents a major health problem highly prevalent in elderly and age-related chronic diseases. Current pharmacological strategies available to prevent and reverse sarcopenia are largely unsatisfactory thus raising the need to identify novel targets for pharmacological intervention and possibly more effective and safe drugs. This review highlights the current knowledge of the potential benefits of renin-angiotensin system blockade in sarcopenia and discuss the main mechanisms underlying the effects.
Pharmacological perspectives in sarcopenia: A potential role for renin-angiotensin system blockers? / Sartiani, Laura; Spinelli, Valentina; Laurino, Annunziatina; Blescia, Sabrina; Raimondi, Laura; Cerbai, Elisabetta; Mugelli, Alessandro. - In: CLINICAL CASES IN MINERAL AND BONE METABOLISM. - ISSN 1724-8914. - ELETTRONICO. - 12:(2015), pp. 135-138. [10.11138/ccmbm/2015.12.2.135]
Pharmacological perspectives in sarcopenia: A potential role for renin-angiotensin system blockers?
SARTIANI, LAURA;SPINELLI, VALENTINA;LAURINO, ANNUNZIATINA;BLESCIA, SABRINA;RAIMONDI, LAURA;CERBAI, ELISABETTA;MUGELLI, ALESSANDRO
2015
Abstract
Sarcopenia represents a major health problem highly prevalent in elderly and age-related chronic diseases. Current pharmacological strategies available to prevent and reverse sarcopenia are largely unsatisfactory thus raising the need to identify novel targets for pharmacological intervention and possibly more effective and safe drugs. This review highlights the current knowledge of the potential benefits of renin-angiotensin system blockade in sarcopenia and discuss the main mechanisms underlying the effects.
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Sartiani etal., 2015Clin Cases Miner Bone Metab.pdf
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