PEGylated proteins are widely used in biomedicine but, in spite of their importance, no atomic-level information is available since they are generally resistant to structural characterization approaches. PEGylated proteins are shown here to yield highly resolved solid-state NMR spectra, which allows assessment of the structural integrity of proteins when PEGylated for therapeutic or diagnostic use.
Solid-State NMR of PEGylated Proteins / Ravera, Enrico; Ciambellotti, Silvia; Cerofolini, Linda; Martelli, Tommaso; Kozyreva, Tatiana; Bernacchioni, Caterina; Giuntini, Stefano; Fragai, Marco; Turano, Paola; Luchinat, Claudio. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - STAMPA. - 55:(2016), pp. 2446-9-2449. [10.1002/anie.201510148]
Solid-State NMR of PEGylated Proteins
RAVERA, ENRICO;CIAMBELLOTTI, SILVIA;CEROFOLINI, LINDA;MARTELLI, TOMMASO;KOZYREVA, TATIANA;BERNACCHIONI, CATERINA;GIUNTINI, STEFANO;FRAGAI, MARCO;TURANO, PAOLA;LUCHINAT, CLAUDIO
2016
Abstract
PEGylated proteins are widely used in biomedicine but, in spite of their importance, no atomic-level information is available since they are generally resistant to structural characterization approaches. PEGylated proteins are shown here to yield highly resolved solid-state NMR spectra, which allows assessment of the structural integrity of proteins when PEGylated for therapeutic or diagnostic use.
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