Anastrozole versus tamoxifen for the prevention of locoregional and contralateral breast cancer in postmenopausal women with locally excised ductal carcinoma in situ (IBIS-II DCIS): A double-blind, randomised controlled trial

Forbes, John F.; Sestak, Ivana; Howell, Anthony; Bonanni, Bernardo; Bundred, Nigel; Levy, Christelle; Von Minckwitz, Gunter; Eiermann, Wolfgang; Neven, Patrick; Stierer, Michael; Holcombe, Chris; Coleman, Robert E.; Jones, Louise; Ellis, Ian; Cuzick, Jack; Sainsbury, R; Garber, J; Warwick, J; Bonanni, B; Buchanan, M; Bundred, N; Buser, K; Cawthorn, S; Coleman, R; Cuzick, J; Dowsett, M; Eastell, R; Ejlertsen, B; Ellis, I; Forbes, J; Howell, A; Kahan, Z; Levy, C; Baclesse, F; Mansel, R; Neven, P; Palva, T; Rydén, L; Stierer, M; Stuart, M; Vaz, F; von Minckwitz, G; Marsiglia, HUGO RAUL; Levy, C; Benyoucef, A; Berton Rigaud, D; Loustalot, C; Serin, D; Kerbrat, P; Eymard, Jc; Giard Lefevre, S; Bonichon Lamichhane, N; Monnier, A; Tubiana Mathieu, N; Piot, G; de Lara, Ct; Bernard, O; Simon Swirski, H; Gladieff, L; Regaud, I; Fouchet Goudier, Mj; Dohollou, N; Aquitaine, N; Elgard Maitre, Am; Bergerat, Jp; Petit, T; Marti, A; Toussaint, C; Del Piano, F; Ibrahim, M; Fric, D; Hönig, A; Müller, V; Marmé, F; Rautenberg, B; Schmidt, M; Hanusch, C; Paepke, S; Kaltenecker, G; Lemster, S; Tio, J; Reimer, T; Schnappauf, B; Baumann, K; Schrader, I; Mundhenke, C; Liedtke, C; Meinerz, W; Thomssen, C; Christl, K; Hitschold, T; Goerke, K; Kast, K; Runnebaum, I; Lindner, C; Scheidel, P; Herwig, U; Bangemann, N; Sommer, H; Göhring, K; Tulusan, A; Stauß, E; Köhler, G; Zahm, D; Augustin, D; Hocke, A; Neunhöffer, T; Schmatloch, S; Heinrich, G; Groß, S; Breitbach, Gp; Scharl, A; Klare, P; Stefek, A; Hoffmann, G; Martignoni, F; Weiss, E; Emons, G; Tesch, Hc; Beckmann, M; Schmutzler, R; Schütte, M; Aktas, B; Hille Betz, U; Deryal, M; Dan Costa, S; Blümel, B; Göhring, Uj; Kleine Tebbe, A; Schumacher, C; Jasmin,; Pourfard, C; Uleer,; Kullmer, U; Krabisch, P; Gätje, R; Schwenzer, T; Hindenburg, Hj; Rempen, A; Höffkes, Hg; Stickeler, E; Reffert, C; Seitz, S; Splitt, G; Böhne, P; Gnauert, K; Strittmatter, Hj; Baake, G; Rezai, M; Noesselt, T; Köhne, Ch; Hanf, V; Strumberg, D; Dall, P; Schleicher, P; Schleicher, B; Beldermann, F; Berghorn, M; Baerens, Dt; Kolberg, Hc; Bauer, L; Brucker, C; Schrader, I; Steck, T; Boyle, F; Forbes, J; Chaudhuri, A; Wagga, W; Moylan, E; Donovan, J; Della Fiorentina, S; Abdi, E; Marx, G; Beadle, G; Donovan, M; Bennett, I; Gill, Pg; Baker, C; Masters, R; Blum, R; Collins, J; Law, M; Hart, S; Baker, C; Kannourakis, G; Snyder, R; Joseph, D; Mccrystal, M; Campbell, I; Jakesz, R; Selim, U; Singer, C; Heck, D; Greil, R; Ramoni, A; Bjelic Radisic, V; Reichenauer, A; Horvath, W; Thaler, J; Fridrik, M; Keckstein, J; Jan, L; L'Hermitte, M; Roelstrate, H; Dirix, L; Bambust, I; Seret, M; Liebens, F; Maerevoet, M; D'Hondt, L; Berliere, M; Nogaret, Jm; Simon, P; Palva, T; Kahan, Z; O'Hanlon, D; Redmond, Hp; Hill, A; Evoy, D; Kerin, M; Gupta, R; Martin, Mj; Fritis, M; Schwartz, R; Yañez, Ml; Peralta, O; Graiff, C; Artioli, F; Generali, D; Orzalesi, Lorenzo; Visini, M; Bonanni, B; Michiara, M; Pavesi, L; Ravaioli, A; Porpiglia, M; Puglisi, F; Pinotti, G; Brincat, S; Buser, Ks; Rabaglio, M; Rauch, D; Chappuis, Po; Zaman, K; Bucher, S; Bolliger, B; Pagani, O; Falck, Ak; Rydén, L; Kaij, J; Margolin, S; Muslumanoglum, M; Bertelli, G; Bramley, M; Bristol, J; Chandrasekharan, S; Crellin, P; Daoud, R; Dodwell, D; Drew, P; Dubey, S; Evans, A; Ferguson, D; Gendy, R; Hamed, H; Harding McKean, C; Holcombe, C; Horgan, K; Iqbal, S; Jibril, Ja; Kokan, J; Kneeshaw, P; Lansdown, M; Lennard, T; Linforth, R; Mansel, R; Mcintosh, S; Mitra, S; Neades, G; Ooi, Jl; Patel, A; Rayter, Z; Reichert, R; Roberts, F; Roche, N; Rogers, C; Royle, G; Shah, E; Sibbering, M; Skene, Ai; Smith, S; Sparrow, G; Thompson, A; Vaidya, J; Wolstenholme, V; Wood, J; Yiangou, C; Zammit, C; Thornton, R; Probert, F; Fong, A; Francis, N; Gili, M; Eigenberger, R; Supply, D; Lefever, I; Muller, B; Zlatar, Z; Feer, P; Gkantiragas, I; Virkki, M; Everhard, S; Lemonnier, J; Garcia, S; Ghanem, S; Cole, A; O'Hare, D; Cronin, E; Roche, T; Kennedy, E; Ballot, J; Killilea, N; Jennings, M; Lowry, L; Maxwell, M; Burke, M; Gonzaga, Ag; Bollani, G; Bianchetti, A; Scalvini, A; Cretella, E; Pasqualini, A; Gobbi, A; Roselli, J; Lagati, A; Rapacchi, E; Lanza, A; Pini, E; Picardo, E; Maggiorotto, F; Sottile, R; Vallini, I; Cilia, N; Patel, M; Bamford, L; Robertshaw, H; Inman, H; Hill, N; Dexter, J; Peasgood, E; Batty, I; Cocks, S; Mistry, R; Sidders, M; Foulstone, E; Garlicka, H; Dawe, C; Elliott, J; Rooke, K; Morris, C; Lester, Y; Gibson, S; Chittock, J; Skelton, A; Gallimore, E; Downes, C; Billett, L; Caddy, S; Cumming, H; Cowell Smith, S; Turner, C; Fernando, S; Goodwin, S; Taylor, Ja; Baines, K; Downer, S; Pilcher, A; Dobson, T; Osborne, L; Kuenzig, G; Hancock, D; Melia, D; Gullaksen, E; Hartup, S; Henson, A; Gibb, J; Coombs, S; Taylor, C; Kirkby, A; Thomas, I; Makinson, K; Kano, Y; Shah, Z; Hardstaff, L; Townley, B; Hill, P; Mccurrie, M; Grassby, S; Henderson, P; Talbot, E; Bell, A; Kanani, R; Johnson, J; Jones, R; Foster, M; Troke, B; Congdon, H; Pascoe, J; Whelan, S; Edwards, J; Brinkworth, E; Blizard, S; Clarke, A; Stevens, K; Harvey, C; Stacey, J; Mitchell, S; Lowry, T; Buckley, S; Collins, C; Green, L; Jones, H; Conteh, V; Ducket, T; Kotze, M; Strider, P; Stouraitis, M; Sundberg, J; Babiker, A; Collins, R; Klijn, J; Ralston, S; Tattersall, M; Weller, I; De Sousa, A; Edwards, R; Ferguson, S; Hickman, J; Johnson, D; Haidar, N; Hammond, V; Heighway, E; Ndoutoumou, A; Sahota, N; White, L; Aigret, B; Batra, P; Knox, J; Oke, A; Ostler, R; Sasieni, P.

doi:10.1016/S0140-6736(15)01129-0

Studio clinico randomizzato dell'utilizzo dell'anastrazolo in comparazione con il Tamoxifene nella prevenzione delle recidive omolaterali e controlaterali in pazienti con Dutal Carcinoma In Situ localmente escissi.

Anastrozole versus tamoxifen for the prevention of locoregional and contralateral breast cancer in postmenopausal women with locally excised ductal carcinoma in situ (IBIS-II DCIS): A double-blind, randomised controlled trial / Forbes, John F.; Sestak, Ivana; Howell, Anthony; Bonanni, Bernardo; Bundred, Nigel; Levy, Christelle; Von Minckwitz, Gunter; Eiermann, Wolfgang; Neven, Patrick; Stierer, Michael; Holcombe, Chris; Coleman, Robert E.; Jones, Louise; Ellis, Ian; Cuzick, Jack; Sainsbury, R; Garber, J; Warwick, J; Bonanni, B; Buchanan, M; Bundred, N; Buser, K; Cawthorn, S; Coleman, R; Cuzick, J; Dowsett, M; Eastell, R; Ejlertsen, B; Ellis, I; Forbes, J; Howell, A; Kahan, Z; Levy, C; Baclesse, F; Mansel, R; Neven, P; Palva, T; Rydén, L; Stierer, M; Stuart, M; Vaz, F; von Minckwitz, G; Marsiglia, H; Levy, C; Benyoucef, A; Berton-Rigaud, D; Loustalot, C; Serin, D; Kerbrat, P; Eymard, Jc; Giard-Lefevre, S; Bonichon-Lamichhane, N; Monnier, A; Tubiana-Mathieu, N; Piot, G; de Lara, Ct; Bernard, O; Simon-Swirski, H; Gladieff, L; Regaud, I; Fouchet-Goudier, Mj; Dohollou, N; Aquitaine, N; Elgard-Maitre, Am; Bergerat, Jp; Petit, T; Marti, A; Toussaint, C; Del Piano, F; Ibrahim, M; Fric, D; Hönig, A; Müller, V; Marmé, F; Rautenberg, B; Schmidt, M; Hanusch, C; Paepke, S; Kaltenecker, G; Lemster, S; Tio, J; Reimer, T; Schnappauf, B; Baumann, K; Schrader, I; Mundhenke, C; Liedtke, C; Meinerz, W; Thomssen, C; Christl, K; Hitschold, T; Goerke, K; Kast, K; Runnebaum, I; Lindner, C; Scheidel, P; Herwig, U; Bangemann, N; Sommer, H; Göhring, K; Tulusan, A; Stauß, E; Köhler, G; Zahm, D; Augustin, D; Hocke, A; Neunhöffer, T; Schmatloch, S; Heinrich, G; Groß, S; Breitbach, Gp; Scharl, A; Klare, P; Stefek, A; Hoffmann, G; Martignoni, F; Weiss, E; Emons, G; Tesch, Hc; Beckmann, M; Schmutzler, R; Schütte, M; Aktas, B; Hille-Betz, U; Deryal, M; Dan Costa, S; Blümel, B; Göhring, Uj; Kleine-Tebbe, A; Schumacher, C; Jasmin, ; Pourfard, C; Uleer, ; Kullmer, U; Krabisch, P; Gätje, R; Schwenzer, T; Hindenburg, Hj; Rempen, A; Höffkes, Hg; Stickeler, E; Reffert, C; Seitz, S; Splitt, G; Böhne, P; Gnauert, K; Strittmatter, Hj; Baake, G; Rezai, M; Noesselt, T; Köhne, Ch; Hanf, V; Strumberg, D; Dall, P; Schleicher, P; Schleicher, B; Beldermann, F; Berghorn, M; Baerens, Dt; Kolberg, Hc; Bauer, L; Brucker, C; Schrader, I; Steck, T; Boyle, F; Forbes, J; Chaudhuri, A; Wagga, W; Moylan, E; Donovan, J; Della-Fiorentina, S; Abdi, E; Marx, G; Beadle, G; Donovan, M; Bennett, I; Gill, Pg; Baker, C; Masters, R; Blum, R; Collins, J; Law, M; Hart, S; Baker, C; Kannourakis, G; Snyder, R; Joseph, D; Mccrystal, M; Campbell, I; Jakesz, R; Selim, U; Singer, C; Heck, D; Greil, R; Ramoni, A; Bjelic-Radisic, V; Reichenauer, A; Horvath, W; Thaler, J; Fridrik, M; Keckstein, J; Jan, L; L'Hermitte, M; Roelstrate, H; Dirix, L; Bambust, I; Seret, M; Liebens, F; Maerevoet, M; D'Hondt, L; Berliere, M; Nogaret, Jm; Simon, P; Palva, T; Kahan, Z; O'Hanlon, D; Redmond, Hp; Hill, A; Evoy, D; Kerin, M; Gupta, R; Martin, Mj; Fritis, M; Schwartz, R; Yañez, Ml; Peralta, O; Graiff, C; Artioli, F; Generali, D; Orzalesi, L; Visini, M; Bonanni, B; Michiara, M; Pavesi, L; Ravaioli, A; Porpiglia, M; Puglisi, F; Pinotti, G; Brincat, S; Buser, Ks; Rabaglio, M; Rauch, D; Chappuis, Po; Zaman, K; Bucher, S; Bolliger, B; Pagani, O; Falck, Ak; Rydén, L; Kaij, J; Margolin, S; Muslumanoglum, M; Bertelli, G; Bramley, M; Bristol, J; Chandrasekharan, S; Crellin, P; Daoud, R; Dodwell, D; Drew, P; Dubey, S; Evans, A; Ferguson, D; Gendy, R; Hamed, H; Harding-McKean, C; Holcombe, C; Horgan, K; Iqbal, S; Jibril, Ja; Kokan, J; Kneeshaw, P; Lansdown, M; Lennard, T; Linforth, R; Mansel, R; Mcintosh, S; Mitra, S; Neades, G; Ooi, Jl; Patel, A; Rayter, Z; Reichert, R; Roberts, F; Roche, N; Rogers, C; Royle, G; Shah, E; Sibbering, M; Skene, Ai; Smith, S; Sparrow, G; Thompson, A; Vaidya, J; Wolstenholme, V; Wood, J; Yiangou, C; Zammit, C; Thornton, R; Probert, F; Fong, A; Francis, N; Gili, M; Eigenberger, R; Supply, D; Lefever, I; Muller, B; Zlatar, Z; Feer, P; Gkantiragas, I; Virkki, M; Everhard, S; Lemonnier, J; Garcia, S; Ghanem, S; Cole, A; O'Hare, D; Cronin, E; Roche, T; Kennedy, E; Ballot, J; Killilea, N; Jennings, M; Lowry, L; Maxwell, M; Burke, M; Gonzaga, Ag; Bollani, G; Bianchetti, A; Scalvini, A; Cretella, E; Pasqualini, A; Gobbi, A; Roselli, J; Lagati, A; Rapacchi, E; Lanza, A; Pini, E; Picardo, E; Maggiorotto, F; Sottile, R; Vallini, I; Cilia, N; Patel, M; Bamford, L; Robertshaw, H; Inman, H; Hill, N; Dexter, J; Peasgood, E; Batty, I; Cocks, S; Mistry, R; Sidders, M; Foulstone, E; Garlicka, H; Dawe, C; Elliott, J; Rooke, K; Morris, C; Lester, Y; Gibson, S; Chittock, J; Skelton, A; Gallimore, E; Downes, C; Billett, L; Caddy, S; Cumming, H; Cowell-Smith, S; Turner, C; Fernando, S; Goodwin, S; Taylor, Ja; Baines, K; Downer, S; Pilcher, A; Dobson, T; Osborne, L; Kuenzig, G; Hancock, D; Melia, D; Gullaksen, E; Hartup, S; Henson, A; Gibb, J; Coombs, S; Taylor, C; Kirkby, A; Thomas, I; Makinson, K; Kano, Y; Shah, Z; Hardstaff, L; Townley, B; Hill, P; Mccurrie, M; Grassby, S; Henderson, P; Talbot, E; Bell, A; Kanani, R; Johnson, J; Jones, R; Foster, M; Troke, B; Congdon, H; Pascoe, J; Whelan, S; Edwards, J; Brinkworth, E; Blizard, S; Clarke, A; Stevens, K; Harvey, C; Stacey, J; Mitchell, S; Lowry, T; Buckley, S; Collins, C; Green, L; Jones, H; Conteh, V; Ducket, T; Kotze, M; Strider, P; Stouraitis, M; Sundberg, J; Babiker, A; Collins, R; Klijn, J; Ralston, S; Tattersall, M; Weller, I; De Sousa, A; Edwards, R; Ferguson, S; Hickman, J; Johnson, D; Haidar, N; Hammond, V; Heighway, E; Ndoutoumou, A; Sahota, N; White, L; Aigret, B; Batra, P; Knox, J; Oke, A; Ostler, R; Sasieni, P.. - In: THE LANCET. - ISSN 0140-6736. - ELETTRONICO. - 387:(2016), pp. 866-873. [10.1016/S0140-6736(15)01129-0]