“Cancer Bio-Immunotherapy in Siena”: Twelfth Meeting of the Network Italiano per la Bioterapia dei Tumori (NIBIT), Siena, Italy, October 9–11, 2014

Cancer immunotherapy has gained a major breakthrough providing novel cancer treatments with high clinical efficacy. The twelfth annual meeting of the Italian Network for Tumor Bio-immunotherapy (NIBIT), organized in cooperation with the NIBIT Foundation, convened in the scenic Tuscan town of Siena with the goal of bringing together leaders in the field of immunotherapy to discuss their recent findings. Moreover, the meeting hosted young investigators presenting their own work. The following topics were discussed in this meeting: (1) mutated antigens and adoptive cell therapy in the clinics; (2) targeting cancer stem cells for immunotherapy; (3) tumor microenvironment and metabolism; (4) new developments in immune oncology; (5) vaccines: pitfalls and promises; (6) checkpoint blockade and targeted therapies in melanoma and other tumors; (7) prognostic and predictive biomarkers in bio-immunotherapy; and (8) ongoing and prospective NIBIT activities and collaborations.