Morin is a natural polyphenol, originally isolated from members of the Moraceae family that can be extracted from leaves, fruits, stems and branches of numerous plants. Several evidence have demonstrated that Morin could have a beneficial effect on several human diseases. In fact, Morin exerts antioxidant, antidiabetic, anti-inflammatory, antitumoral, antihypertensive, antibacterial, hypouricemic, and neuroprotective effects, by modulating the activity of many enzymes. In some cases, Morin shows a systemic protective action, reducing negative side effects of several drugs, without interfering with their functions. In addition, in vitro and in vivo studies demonstrated that Morin exhibits very low toxicity levels and its chronic administration is well tolerated. All these findings suggest that Morin could be used, either alone or in combination with other drugs, to prevent many human pathologies.

Morin: A Promising Natural Drug / Caselli, Anna; Cirri, Paolo; Santi, Alice; Paoli, Paolo. - In: CURRENT MEDICINAL CHEMISTRY. - ISSN 1875-533X. - ELETTRONICO. - 23:(2016), pp. 774-791. [10.2174/0929867323666160106150821]

Morin: A Promising Natural Drug

CASELLI, ANNA;CIRRI, PAOLO;SANTI, ALICE;PAOLI, PAOLO
2016

Abstract

Morin is a natural polyphenol, originally isolated from members of the Moraceae family that can be extracted from leaves, fruits, stems and branches of numerous plants. Several evidence have demonstrated that Morin could have a beneficial effect on several human diseases. In fact, Morin exerts antioxidant, antidiabetic, anti-inflammatory, antitumoral, antihypertensive, antibacterial, hypouricemic, and neuroprotective effects, by modulating the activity of many enzymes. In some cases, Morin shows a systemic protective action, reducing negative side effects of several drugs, without interfering with their functions. In addition, in vitro and in vivo studies demonstrated that Morin exhibits very low toxicity levels and its chronic administration is well tolerated. All these findings suggest that Morin could be used, either alone or in combination with other drugs, to prevent many human pathologies.
2016
23
774
791
Caselli, Anna; Cirri, Paolo; Santi, Alice; Paoli, Paolo
File in questo prodotto:
File Dimensione Formato  
Caselli_2016_CMC.pdf

Accesso chiuso

Tipologia: Pdf editoriale (Version of record)
Licenza: Tutti i diritti riservati
Dimensione 501.71 kB
Formato Adobe PDF
501.71 kB Adobe PDF   Richiedi una copia
2158-1041583_preprint.pdf

accesso aperto

Tipologia: Preprint (Submitted version)
Licenza: Open Access
Dimensione 1.14 MB
Formato Adobe PDF
1.14 MB Adobe PDF

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1041583
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 184
  • ???jsp.display-item.citation.isi??? 168
social impact