BACKGROUND: We report here a case of a woman affected by fever, weight loss, splenomegaly, and leucopenia associated with trombocytopenia, transferred to the intensive care unit with acute kidney injury and septic shock. METHODS: Patient was treated with high cut-off continuous veno-venous hemodialysis (HCO-CVVHD). RESULTS: During treatment, the patient experienced a stable improvement in the hemodynamic, pulmonary function and tissue perfusion parameters. After 48 h of treatment, significant reductions in SOFA score (from 12, before starting the procedure, to 6) and in serum inflammatory mediators (as IL-6, from 599-568 pg/ml) were observed. Leishmania infection was identified as responsible of the septic condition only 48 h after removing hemodialysis. Antiprotozoal therapy was begun and the patient discharged. CONCLUSIONS: By supporting the renal function and reducing systemic inflammation, HCO-CVVHD could be a useful bridge therapy. This procedure allowed the medical team to gain sufficient time to diagnose the type of infection and begin an etiological therapy

Role of hemodialysis with high cut-off membranes in a patient with a non-recognized leishmaniasis / Villa, Gianluca; D'Alfonso, Maria Grazia; Di Maggio, Paola; Berardi, Margherita; Chelazzi, Cosimo; Caldini, Anna Lucia; De Gaudio, A. Raffaele; Gensini, Gian Franco; Valente, Serafina. - In: BLOOD PURIFICATION. - ISSN 0253-5068. - ELETTRONICO. - 38:(2014), pp. 239-241. [10.1159/000368958]

Role of hemodialysis with high cut-off membranes in a patient with a non-recognized leishmaniasis

VILLA, GIANLUCA;D'ALFONSO, MARIA GRAZIA;BERARDI, MARGHERITA;CHELAZZI, COSIMO;GENSINI, GIAN FRANCO;
2014

Abstract

BACKGROUND: We report here a case of a woman affected by fever, weight loss, splenomegaly, and leucopenia associated with trombocytopenia, transferred to the intensive care unit with acute kidney injury and septic shock. METHODS: Patient was treated with high cut-off continuous veno-venous hemodialysis (HCO-CVVHD). RESULTS: During treatment, the patient experienced a stable improvement in the hemodynamic, pulmonary function and tissue perfusion parameters. After 48 h of treatment, significant reductions in SOFA score (from 12, before starting the procedure, to 6) and in serum inflammatory mediators (as IL-6, from 599-568 pg/ml) were observed. Leishmania infection was identified as responsible of the septic condition only 48 h after removing hemodialysis. Antiprotozoal therapy was begun and the patient discharged. CONCLUSIONS: By supporting the renal function and reducing systemic inflammation, HCO-CVVHD could be a useful bridge therapy. This procedure allowed the medical team to gain sufficient time to diagnose the type of infection and begin an etiological therapy
2014
38
239
241
Villa, Gianluca; D'Alfonso, Maria Grazia; Di Maggio, Paola; Berardi, Margherita; Chelazzi, Cosimo; Caldini, Anna Lucia; De Gaudio, A. Raffaele; Gensin...espandi
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1043462
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 5
social impact