In a double-blind, randomized, crossover study, the antihypertensive efficacy of ramipril, a new angiotensin converting enzyme inhibitor, was compared with that of enalapril in 20 patients with mild hypertension. Patients underwent ambulatory blood pressure monitoring after a 4-week washout period and after 2 and 4 weeks of treatment. After 2 weeks of treatment, both ramipril and enalapril significantly reduced systolic (P < 0.03 and P < 0.002, respectively) and diastolic (P < 0.008 and P < 0.04, respectively) 24-hour blood pressures. No differences were found between treatments. After 4 weeks of treatment, both drugs continued to reduce 24-hour systolic (P < 0.002 and P < 0.03 for ramipril and enalapril, respectively) and diastolic blood pressures (P < 0.001 and P < 0.05 for ramipril and enalapril, respectively). The effect of ramipril on 24-hour blood pressure was greater than that of enalapril, but the differences did not reach statistical significance. These results demonstrate that the antihypertensive effects of ramipril and enalapril are comparable.
Twenty-four-hour antihypertensive efficacy of ramipril and enalapril / Modesti, Pietro Amedeo; Said, Abdirasag Mohamed; Cecioni, Ilaria; Mininni, Simone; Pieri, Francesco. - In: CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL. - ISSN 0011-393X. - STAMPA. - 53:(1993), pp. 137-143. [10.1016/S0011-393X(05)80238-3]
Twenty-four-hour antihypertensive efficacy of ramipril and enalapril
MODESTI, PIETRO AMEDEO;
1993
Abstract
In a double-blind, randomized, crossover study, the antihypertensive efficacy of ramipril, a new angiotensin converting enzyme inhibitor, was compared with that of enalapril in 20 patients with mild hypertension. Patients underwent ambulatory blood pressure monitoring after a 4-week washout period and after 2 and 4 weeks of treatment. After 2 weeks of treatment, both ramipril and enalapril significantly reduced systolic (P < 0.03 and P < 0.002, respectively) and diastolic (P < 0.008 and P < 0.04, respectively) 24-hour blood pressures. No differences were found between treatments. After 4 weeks of treatment, both drugs continued to reduce 24-hour systolic (P < 0.002 and P < 0.03 for ramipril and enalapril, respectively) and diastolic blood pressures (P < 0.001 and P < 0.05 for ramipril and enalapril, respectively). The effect of ramipril on 24-hour blood pressure was greater than that of enalapril, but the differences did not reach statistical significance. These results demonstrate that the antihypertensive effects of ramipril and enalapril are comparable.File | Dimensione | Formato | |
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