Background The enhanced cardiac angiotensin (Ang) II production in human failing ventricles is associated with an Increased expression of proinflammatory cytokines. We assessed the hypothesis that in failing myocytes the Ang II evoked signalling is readdressed versus the activation of intracellular signaling not elicited in the normal heart.
Altered angiotensin II-induced activation of intracellular signalling pathways in failing human ventricular myocytes / Modesti, Pietro A.; Modesti, Alessandra; Vanni, Simone; Toscano, Thomas; Cecioni, Ilaria; Gamberi, Tania; Bertolozzi, Iacopo; Maccherini, Massimo; Neri Serneri, Giangastone. - In: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. - ISSN 0735-1097. - STAMPA. - 41:(2003), pp. 193-193. [10.1016/S0735-1097(03)81928-9]
Altered angiotensin II-induced activation of intracellular signalling pathways in failing human ventricular myocytes
MODESTI, PIETRO AMEDEO;MODESTI, ALESSANDRA;Vanni, Simone;GAMBERI, TANIA;NERI SERNERI, GIAN GASTONE
2003
Abstract
Background The enhanced cardiac angiotensin (Ang) II production in human failing ventricles is associated with an Increased expression of proinflammatory cytokines. We assessed the hypothesis that in failing myocytes the Ang II evoked signalling is readdressed versus the activation of intracellular signaling not elicited in the normal heart.
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