INTRODUCTION: Pleural effusion as the first clinical manifestation of acute lymphoblastic leukemia (ALL) is a relatively rare event. An early and accurate diagnosis of this clinical picture is very important for adequate patient management. CASE PRESENTATION: We report the atypical onset of T-lineage ALL in a 31-year-old man. The patient was admitted to the emergency room due to lung failure; at that moment, the patient's initial blood count was normal; the chest X-ray radiography showed a massive pleural effusion and a thoracentesis was carried out. Routine investigations performed on the pleural fluid using a new technology system and digitalized cell analysis demonstrated infiltration by immature cells. Therefore, bone marrow aspirate and flow cytometry analyses were performed, leading to the diagnosis of T-lineage ALL. A cord blood transplantation procedure was performed at the first hematological remission following chemotherapy regimens. The patient died of septic shock. CONCLUSION: The case we reported underlines the usefulness of using automated instruments to identify abnormal lymphoid cells in body fluids.

Diagnosis of a T-lineage acute Lymphoblastic leukemia through digitalized cell analysis of the pleural effusion / Peruzzi, Benedetta; Cutini, Ilaria; Gelli, Anna Maria Grazia; Rondelli, Tommaso; Statello, Marinella; Bencini, Sara; Mannelli, Francesco; Caporale, Roberto; Bosi, Alberto; Fanelli, Alessandra. - In: INTERNATIONAL MEDICAL CASE REPORTS JOURNAL. - ISSN 1179-142X. - ELETTRONICO. - 6:(2013), pp. 77-80. [10.2147/IMCRJ.S49278]

Diagnosis of a T-lineage acute Lymphoblastic leukemia through digitalized cell analysis of the pleural effusion

Mannelli, Francesco;BOSI, ALBERTO;
2013

Abstract

INTRODUCTION: Pleural effusion as the first clinical manifestation of acute lymphoblastic leukemia (ALL) is a relatively rare event. An early and accurate diagnosis of this clinical picture is very important for adequate patient management. CASE PRESENTATION: We report the atypical onset of T-lineage ALL in a 31-year-old man. The patient was admitted to the emergency room due to lung failure; at that moment, the patient's initial blood count was normal; the chest X-ray radiography showed a massive pleural effusion and a thoracentesis was carried out. Routine investigations performed on the pleural fluid using a new technology system and digitalized cell analysis demonstrated infiltration by immature cells. Therefore, bone marrow aspirate and flow cytometry analyses were performed, leading to the diagnosis of T-lineage ALL. A cord blood transplantation procedure was performed at the first hematological remission following chemotherapy regimens. The patient died of septic shock. CONCLUSION: The case we reported underlines the usefulness of using automated instruments to identify abnormal lymphoid cells in body fluids.
2013
6
77
80
Peruzzi, Benedetta; Cutini, Ilaria; Gelli, Anna Maria Grazia; Rondelli, Tommaso; Statello, Marinella; Bencini, Sara; Mannelli, Francesco; Caporale, Roberto; Bosi, Alberto; Fanelli, Alessandra
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1046265
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