The cells of the immune system undergo two different kinds of apoptotic processes: activation-induced cell death (AICD), peculiar to immune cells, and damage-induced cell death (DICD), a more generalized phenomenon in response to a variety of cellular insults, mainly oxidative metabolism by-products. AICD is geared towards the elimination of unnecessary lymphocytes following clonal expansion that results from antigenic stimulation, whereas DICD is particularly important for preventing the onset of neoplastic proliferation. We hypothesize that both oxidative stress and chronic antigenic load, which impinge heavily on the immune system, induce decreased lymphocyte susceptibility to DICD and a proinflammatory status leading to increased AICD. This subtle remodeling of AICD and DICD drives immunosenescence, contributing to the phenotypic and functional characteristics of the elderly immune system.

CHRONIC ANTIGENIC LOAD AND APOPTOSIS IN IMMUNOSENESCENCE / L.Ginaldi ; M.De Martinis ; D.Monti ; C.Franceschi. - In: TRENDS IN IMMUNOLOGY. - ISSN 1471-4906. - STAMPA. - 26:(2005), pp. 79-89.

CHRONIC ANTIGENIC LOAD AND APOPTOSIS IN IMMUNOSENESCENCE.

MONTI, DANIELA;
2005

Abstract

The cells of the immune system undergo two different kinds of apoptotic processes: activation-induced cell death (AICD), peculiar to immune cells, and damage-induced cell death (DICD), a more generalized phenomenon in response to a variety of cellular insults, mainly oxidative metabolism by-products. AICD is geared towards the elimination of unnecessary lymphocytes following clonal expansion that results from antigenic stimulation, whereas DICD is particularly important for preventing the onset of neoplastic proliferation. We hypothesize that both oxidative stress and chronic antigenic load, which impinge heavily on the immune system, induce decreased lymphocyte susceptibility to DICD and a proinflammatory status leading to increased AICD. This subtle remodeling of AICD and DICD drives immunosenescence, contributing to the phenotypic and functional characteristics of the elderly immune system.
2005
26
79
89
L.Ginaldi ; M.De Martinis ; D.Monti ; C.Franceschi
File in questo prodotto:
File Dimensione Formato  
Trends immunol 2005.pdf

Accesso chiuso

Tipologia: Versione finale referata (Postprint, Accepted manuscript)
Licenza: Tutti i diritti riservati
Dimensione 144.28 kB
Formato Adobe PDF
144.28 kB Adobe PDF   Richiedi una copia

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/10479
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 55
  • ???jsp.display-item.citation.isi??? 42
social impact