The heart of the obsessional process may be considered the subject’s underlying impression that “something is wrong” or “that something isn’t just as it should be”. This phenomenon, labeled “not just right experiences” (NJREs), has increasingly been receiving attention as a possible marker of obsessive-compulsive disorder (OCD). The present study sought to add to the evidence that NJREs may be a putative endophenotype of obsessional symptoms. To this aim, measures of NJREs, obsessive-compulsive (OC) symptoms and psychological distress were compared in offspring of parents with and without OC symptoms. The offspring of parents with OC symptoms (N=120) reported higher frequency and severity of NJREs compared to offspring of parents without OC symptoms (N=106). Such differences remained significant for NJREs frequency and close to significance for NJREs severity, when general distress (i.e., anxiety and depression) was controlled. The possible role of NJREs as an endophenotype for OCD is discussed in reference to Gottesman and Gould criteria and the National Institute of Mental Health RDoC initiative.

“Not Just Right Experiences” as a psychological endophenotype for obsessive-compulsive disorder: Evidence from an Italian family study / Sica, Claudio; Bottesi, Gioia; Caudek, Corrado; Orsucci, Antonella; Ghisi, Marta. - In: PSYCHIATRY RESEARCH. - ISSN 0165-1781. - STAMPA. - 245:(2016), pp. 27-35. [10.1016/j.psychres.2016.08.005]

“Not Just Right Experiences” as a psychological endophenotype for obsessive-compulsive disorder: Evidence from an Italian family study

SICA, CLAUDIO;CAUDEK, CORRADO;
2016

Abstract

The heart of the obsessional process may be considered the subject’s underlying impression that “something is wrong” or “that something isn’t just as it should be”. This phenomenon, labeled “not just right experiences” (NJREs), has increasingly been receiving attention as a possible marker of obsessive-compulsive disorder (OCD). The present study sought to add to the evidence that NJREs may be a putative endophenotype of obsessional symptoms. To this aim, measures of NJREs, obsessive-compulsive (OC) symptoms and psychological distress were compared in offspring of parents with and without OC symptoms. The offspring of parents with OC symptoms (N=120) reported higher frequency and severity of NJREs compared to offspring of parents without OC symptoms (N=106). Such differences remained significant for NJREs frequency and close to significance for NJREs severity, when general distress (i.e., anxiety and depression) was controlled. The possible role of NJREs as an endophenotype for OCD is discussed in reference to Gottesman and Gould criteria and the National Institute of Mental Health RDoC initiative.
2016
245
27
35
Sica, Claudio; Bottesi, Gioia; Caudek, Corrado; Orsucci, Antonella; Ghisi, Marta
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1052322
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