The iLA-activve(®) Novalung is a new extracorporeal device specifically designed for lung support in patients with hypercapnic and/or hypoxemic respiratory failure. To date, only low-flow applications for decompensated hypercapnic chronic obstructive pulmonary disease have been reported in the literature. Here, we briefly report three cases of iLA-activve use in patients with hypercapnic-hypoxemic acute lung failure assisted with mid-flow (up to 2.4 L/min) and different single/double venous cannulation. The main findings of our small case series were: firstly, extracorporeal blood flows over 2.0 L/min across the membrane provided clinically satisfying decarboxylation and improved oxygenation; secondly, the ratio between blood flow through the membrane and the patient's cardiac output (CO) was a major determinant for the oxygen increase. The latter could, therefore, be a useful indicator for understanding performance in the complex and multifactorial evaluation of patients with extracorporeal veno-venous lung support.

Cardiac output: a central issue in patients with respiratory extracorporeal support / Romagnoli, Stefano; Zagli, Giovanni; Ricci, Zaccaria; Villa, Gianluca; Barbani, Francesco; Pinelli, Fulvio; De Gaudio, Raffaele; Chelazzi, Cosimo. - In: PERFUSION-UK. - ISSN 0267-6591. - ELETTRONICO. - (2016), pp. 0-0. [10.1177/0267659116658112]

Cardiac output: a central issue in patients with respiratory extracorporeal support

ROMAGNOLI, STEFANO;ZAGLI, GIOVANNI;VILLA, GIANLUCA;BARBANI, FRANCESCO;
2016

Abstract

The iLA-activve(®) Novalung is a new extracorporeal device specifically designed for lung support in patients with hypercapnic and/or hypoxemic respiratory failure. To date, only low-flow applications for decompensated hypercapnic chronic obstructive pulmonary disease have been reported in the literature. Here, we briefly report three cases of iLA-activve use in patients with hypercapnic-hypoxemic acute lung failure assisted with mid-flow (up to 2.4 L/min) and different single/double venous cannulation. The main findings of our small case series were: firstly, extracorporeal blood flows over 2.0 L/min across the membrane provided clinically satisfying decarboxylation and improved oxygenation; secondly, the ratio between blood flow through the membrane and the patient's cardiac output (CO) was a major determinant for the oxygen increase. The latter could, therefore, be a useful indicator for understanding performance in the complex and multifactorial evaluation of patients with extracorporeal veno-venous lung support.
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Romagnoli, Stefano; Zagli, Giovanni; Ricci, Zaccaria; Villa, Gianluca; Barbani, Francesco; Pinelli, Fulvio; De Gaudio, Raffaele; Chelazzi, Cosimo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2158/1052996
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