PS1-076. Redirection of allergen-specific TH2 cells by a modified adenine chemically coupled to allergenic molecule(s)

In two previous papers we described a substituted 8-hydroxyadenine named SA-2 as able to in vitro revert the TH2 phenotype of human allergen specific T cells and to in vivo inhibit allergic lung inflammation in a OVA-specific mouse model of asthma by triggering TLR7. As the conjugation of the adjuvant to the allergen is an efficacious strategy of allergen immunotherapy because it enhances the immunogenicity and reduces the allergenicity of the vaccine, we synthetized another adenine derivative named SA-26E, which was chemically conjugated to the purified natural allergen Der p2 (nDer p2-Conj) from Dermatophagoides pteronyssinus and we assessed this conjugate for its immunomodulatory activity on human cells.