The process for using statistical inference to establish personalized treatment strategies requires specific techniques for data-analysis that optimize the combination of competing therapies with candidate genetic features and characteristics of the patient and disease. A wide variety of methods have been developed. However, heretofore the usefulness of these recent advances has not been fully recognized by the oncology community, and the scope of their applications has not been summarized. In this paper, we provide an overview of statistical methods for establishing optimal treatment rules for personalized medicine and discuss specific examples in various medical contexts with oncology as an emphasis. We also point the reader to statistical software for implementation of the methods when available.

Statistical Methods for Establishing Personalized Treatment Rules in Oncology / Ma, Junsheng; Hobbs, Brian P.; Stingo, Francesco C. - In: BIOMED RESEARCH INTERNATIONAL. - ISSN 2314-6133. - ELETTRONICO. - 2015:(2015), pp. 1-13. [10.1155/2015/670691]

Statistical Methods for Establishing Personalized Treatment Rules in Oncology

STINGO, FRANCESCO CLAUDIO
2015

Abstract

The process for using statistical inference to establish personalized treatment strategies requires specific techniques for data-analysis that optimize the combination of competing therapies with candidate genetic features and characteristics of the patient and disease. A wide variety of methods have been developed. However, heretofore the usefulness of these recent advances has not been fully recognized by the oncology community, and the scope of their applications has not been summarized. In this paper, we provide an overview of statistical methods for establishing optimal treatment rules for personalized medicine and discuss specific examples in various medical contexts with oncology as an emphasis. We also point the reader to statistical software for implementation of the methods when available.
2015
2015
1
13
Ma, Junsheng; Hobbs, Brian P.; Stingo, Francesco C
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1054628
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