Due to their tunable surface plasmon and functional photothermal effects, gold nanorods (GNRs) have proved to be promising in a wide range of biomedical applications such as imaging, hyperthermia therapy and drug delivery. All these applications can be controlled by the use of near infrared (NIR) light, which can penetrate deep into human tissues with minimal invasiveness. AuNRs thus hold the potential to combine both imaging diagnosis and therapeutic treatment into one single platform. Targeting of cancer cells by such devices can be carried out by three different strategies: 1) passive targeting based on the Enhanced Permeability and Retention (EPR) effect. Polyethylene glycol modified (PEGylated) GNRs tend to accumulate into tumors after intravenous injection much more than they do into normal tissue because of the leaky vasculature and the poor drainage of tumoral tissues; 2) active targeting which involves the immobilization of a selective ligand onto the surface of the GNRs; 3) the exploitation of cellular vehicles, i.e. cells that exhibit tropism to a lesion.
Strategies for tumor targeting by gold nanorods / Centi, S.; Ratto, F.; Borri, C.; Tatini, F.; Pini, R.; Borri, C.; Fusi, F.; Colagrande, S.. - ELETTRONICO. - (2015), pp. 1-5. (Intervento presentato al convegno 3rd IEEE International Conference on BioPhotonics, BioPhotonics 2015 tenutosi a Meeting Center of Florence Research Area of the Italian National Research Council, ita nel 2015) [10.1109/BioPhotonics.2015.7304033].
Strategies for tumor targeting by gold nanorods
BORRI, CLAUDIA;FUSI, FRANCO;COLAGRANDE, STEFANO
2015
Abstract
Due to their tunable surface plasmon and functional photothermal effects, gold nanorods (GNRs) have proved to be promising in a wide range of biomedical applications such as imaging, hyperthermia therapy and drug delivery. All these applications can be controlled by the use of near infrared (NIR) light, which can penetrate deep into human tissues with minimal invasiveness. AuNRs thus hold the potential to combine both imaging diagnosis and therapeutic treatment into one single platform. Targeting of cancer cells by such devices can be carried out by three different strategies: 1) passive targeting based on the Enhanced Permeability and Retention (EPR) effect. Polyethylene glycol modified (PEGylated) GNRs tend to accumulate into tumors after intravenous injection much more than they do into normal tissue because of the leaky vasculature and the poor drainage of tumoral tissues; 2) active targeting which involves the immobilization of a selective ligand onto the surface of the GNRs; 3) the exploitation of cellular vehicles, i.e. cells that exhibit tropism to a lesion.File | Dimensione | Formato | |
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