Therapy-related myeloid neoplasms (t-MN) occur in patients who received cytotoxic therapies for prior malignancy or, rarely, for non-malignant diseases.1 With the improvement of chemotherapeutic regimens and supportive care measures, increased long-term cancer survivors have lead to an increased incidence of t-MN. t-MN, including therapy-related myelodysplastic syndromes (t-MDS) and therapy-related acute myeloid leukemia (t-AML), are clinically aggressive compared with their de novo counterparts.2 Owing to a generally poor outcome of affected patients,3 in the 2008 World Health Organization (WHO) classification, t-MDS and t-AML are not considered sufficiently distinctive and classified together under t-MN.

Application of the international prognostic scoring System-Revised in therapy-related myelodysplastic syndromes and oligoblastic acute myeloid leukemia / Ok, C.Y.; Hasserjian, R.P.; Fox, P.S.; Stingo, F.; Zuo, Z.; Young, K.H.; Patel, K.; Medeiros, L.J.; Garcia-Manero, G.; Wang, S.A.. - In: LEUKEMIA. - ISSN 0887-6924. - STAMPA. - 28:(2014), pp. 185-189. [10.1038/leu.2013.191]

Application of the international prognostic scoring System-Revised in therapy-related myelodysplastic syndromes and oligoblastic acute myeloid leukemia

STINGO, FRANCESCO CLAUDIO;
2014

Abstract

Therapy-related myeloid neoplasms (t-MN) occur in patients who received cytotoxic therapies for prior malignancy or, rarely, for non-malignant diseases.1 With the improvement of chemotherapeutic regimens and supportive care measures, increased long-term cancer survivors have lead to an increased incidence of t-MN. t-MN, including therapy-related myelodysplastic syndromes (t-MDS) and therapy-related acute myeloid leukemia (t-AML), are clinically aggressive compared with their de novo counterparts.2 Owing to a generally poor outcome of affected patients,3 in the 2008 World Health Organization (WHO) classification, t-MDS and t-AML are not considered sufficiently distinctive and classified together under t-MN.
2014
28
185
189
Ok, C.Y.; Hasserjian, R.P.; Fox, P.S.; Stingo, F.; Zuo, Z.; Young, K.H.; Patel, K.; Medeiros, L.J.; Garcia-Manero, G.; Wang, S.A.
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1054924
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