Juvenile Idiopathic Arthritis (JIA) encompasses a group of diseases of unknown etiology having in common arthritis in at least 1 joint that persists for 6 weeks and begins before 16 years of age, with other conditions excluded. With a prevalence of 1 per 1,000 children in the USA, JIA is the most common pediatric rheumatic illness and a major cause of acquired childhood disability. During the last 20 years, the advent of host immune response modifiers known as biologic agents, in particular the anti-TNFα agents (etanercept, infliximab, adalimumab), which directly inhibit the action of pro-inflammatory mediators, has revolutionized the treatment and the expected outcome of JIA. This article highlights treatment indications of anti-TNFα drugs and their more frequent side effects in JIA patients.
Recent advances in the use of Anti-TNFα therapy for the treatment of juvenile idiopathic arthritis / Taddio, Andrea; Cattalini, Marco; Simonini, Gabriele; Cimaz, Rolando. - In: EXPERT REVIEW OF CLINICAL IMMUNOLOGY. - ISSN 1744-8409. - STAMPA. - 12:(2016), pp. 641-649. [10.1586/1744666X.2016.1146132]
Recent advances in the use of Anti-TNFα therapy for the treatment of juvenile idiopathic arthritis
SIMONINI, GABRIELE;CIMAZ, ROLANDO
2016
Abstract
Juvenile Idiopathic Arthritis (JIA) encompasses a group of diseases of unknown etiology having in common arthritis in at least 1 joint that persists for 6 weeks and begins before 16 years of age, with other conditions excluded. With a prevalence of 1 per 1,000 children in the USA, JIA is the most common pediatric rheumatic illness and a major cause of acquired childhood disability. During the last 20 years, the advent of host immune response modifiers known as biologic agents, in particular the anti-TNFα agents (etanercept, infliximab, adalimumab), which directly inhibit the action of pro-inflammatory mediators, has revolutionized the treatment and the expected outcome of JIA. This article highlights treatment indications of anti-TNFα drugs and their more frequent side effects in JIA patients.I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.