INTRODUCTION & OBJECTIVES: Absence of surgical complications represents an important perioperative goal of partial nephrectomy (PN). The aim of this study is to analyse intra and postoperative complications related to NSS in clinical T1 renal tumours in a wide Italian multicentre dataset and to search for possible predictive factors. MATERIAL & METHODS: Overall, 1075 patients treated with nephron sparing surgery (NSS) for clinical renal tumours between January 2009 and December 2012 were prospectively recorded. Overall, 550 (57%) patients had open NSS, 297 (30.8%) a laparoscopic and 118 (12.2%) a robotic approach. Centres were divided in high and low volume according to the threshold of 50 interventions per year. A description of cT1 cases (n=965) and a uni- and multivariate analysis for surgical complication were performed. RESULTS: Overall, 965 patients were analysed. 4.9% had Intraoperative complications (3% for pleural injuries, 1% for vascular injuries, 0.3% for spleen injuries, 0.6% for other causes). Overall, in 13.3% of patients occur postoperative surgical complications (7.6% surgical Clavien 2 and 3.8% surgical Clavien 3). Overall, 6.4% of patients had postoperative medical complications (3.2% were respiratory, 1.9% were cardiologic, 0.2% were thromboembolisms and 1.1% for other causes). At multivariate analysis ECOG score ≥1 (OR 1.9, CI 1.21-3.10, p 0.01), clinical diameter (OR 1.42, CI 0.1.07-1.90, p 0.02), open approach (OR 3.2, CI 1.11-9.30, p 0.03), and estimated blood loss (EBL) (OR 1.01, CI 1.00-1.01, p 0.01) were significant predictive factor of surgical postop complications. Intraoperative complications at univariate analysis were predictive factors for surgical postop complications (p=0.0001), but did not achieve significance at multivariate analysis (OR 2.08, CI 0.94-4.59, p 0.07). CONCLUSIONS: In this study comorbidity status (ECOG score) and clinical diameter of the tumour are the only preoperative significant predictive factors of surgical complications, along with higher EBL and the open approach.

Prospective analysis of complications and their predictive factors after partial nephrectomy in a multicenter comparative Italian study (RECORd1) / Minervini, A.; Mari, A.; Antonelli, A; Bertolo, R; Bianchi, G; Borghesi, M; Cocci, A.; Fiori, C; Longo, N; Martorana, G.; Mirone, V.; Morgia, G; Novara, G; Porpiglia, F; Rovereto, B; Schiavina, R; Serni, S; Simeone, C; Sodano, M; Terrone, C; Carini, M.. - In: EUROPEAN UROLOGY. SUPPLEMENTS. - ISSN 1569-9056. - STAMPA. - 14:(2015), pp. 109-109.

Prospective analysis of complications and their predictive factors after partial nephrectomy in a multicenter comparative Italian study (RECORd1)

MINERVINI, ANDREA;Mari, A.;LONGO, NICOLA;SERNI, SERGIO;SIMEONE, FELICE CARLO;CARINI, MARCO
2015

Abstract

INTRODUCTION & OBJECTIVES: Absence of surgical complications represents an important perioperative goal of partial nephrectomy (PN). The aim of this study is to analyse intra and postoperative complications related to NSS in clinical T1 renal tumours in a wide Italian multicentre dataset and to search for possible predictive factors. MATERIAL & METHODS: Overall, 1075 patients treated with nephron sparing surgery (NSS) for clinical renal tumours between January 2009 and December 2012 were prospectively recorded. Overall, 550 (57%) patients had open NSS, 297 (30.8%) a laparoscopic and 118 (12.2%) a robotic approach. Centres were divided in high and low volume according to the threshold of 50 interventions per year. A description of cT1 cases (n=965) and a uni- and multivariate analysis for surgical complication were performed. RESULTS: Overall, 965 patients were analysed. 4.9% had Intraoperative complications (3% for pleural injuries, 1% for vascular injuries, 0.3% for spleen injuries, 0.6% for other causes). Overall, in 13.3% of patients occur postoperative surgical complications (7.6% surgical Clavien 2 and 3.8% surgical Clavien 3). Overall, 6.4% of patients had postoperative medical complications (3.2% were respiratory, 1.9% were cardiologic, 0.2% were thromboembolisms and 1.1% for other causes). At multivariate analysis ECOG score ≥1 (OR 1.9, CI 1.21-3.10, p 0.01), clinical diameter (OR 1.42, CI 0.1.07-1.90, p 0.02), open approach (OR 3.2, CI 1.11-9.30, p 0.03), and estimated blood loss (EBL) (OR 1.01, CI 1.00-1.01, p 0.01) were significant predictive factor of surgical postop complications. Intraoperative complications at univariate analysis were predictive factors for surgical postop complications (p=0.0001), but did not achieve significance at multivariate analysis (OR 2.08, CI 0.94-4.59, p 0.07). CONCLUSIONS: In this study comorbidity status (ECOG score) and clinical diameter of the tumour are the only preoperative significant predictive factors of surgical complications, along with higher EBL and the open approach.
2015
Minervini, A.; Mari, A.; Antonelli, A; Bertolo, R; Bianchi, G; Borghesi, M; Cocci, A.; Fiori, C; Longo, N; Martorana, G.; Mirone, V.; Morgia, G; Novar...espandi
File in questo prodotto:
File Dimensione Formato  
109-Prospective-analysis-of-complications-and-their-predictive-factors-after-partial-nephrectomy-in-a-multicenter-comparative-Italian-study-RECORd1-_2 - Copia.pdf

accesso aperto

Tipologia: Pdf editoriale (Version of record)
Licenza: Open Access
Dimensione 1.84 MB
Formato Adobe PDF
1.84 MB Adobe PDF

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1056696
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 0
social impact