This study presents the analyses of urinary biomarkers (1-OHPyr, α- and β-naphthols) of polycyclic aromatic hydrocarbons (PAHs) exposure and biomarkers of effect (i.e. blood parameters) in petroleum-refinery workers (RFs) and auto-repair workers (MCs). Exposed subjects had higher concentrations of white blood cell (WBC) count than control subjects (CN) subjects (5.31 × 103 μL−1 in exposed vs. 5.15 × 103 μL−1 in CN subjects), while the biomarker of oxidative DNA damage (8-OHdG) was significantly higher in MCs. The exposure among these two cohorts could be influenced by the ambience of the workplaces; in fact, MCs’ shops are relatively damp and enclosed workplaces in comparison with the indoor environment of refineries. PAHs in the dust samples from mechanical workshops probably originated from mixed sources (traffic exhaust and petroleum spills), while the incremental lifetime cancer risk (ILCR) for MCs showed moderate-to-low cancer risk from exposure to dust-bound PAHs. The study shows that increasing PAH exposure can be traced in MC workstations and needs to be investigated for the safety of public health.

Health and carcinogenic risk evaluation for cohorts exposed to PAHs in petrochemical workplaces in Rawalpindi city (Pakistan) / Kamal, Atif; Cincinelli, Alessandra; Martellini, Tania; Palchetti, Ilaria; Bettazzi, Francesca; Malik, Riffat Naseem. - In: INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH. - ISSN 0960-3123. - STAMPA. - 26:(2016), pp. 37-57. [10.1080/09603123.2015.1007843]

Health and carcinogenic risk evaluation for cohorts exposed to PAHs in petrochemical workplaces in Rawalpindi city (Pakistan)

CINCINELLI, ALESSANDRA;MARTELLINI, TANIA;PALCHETTI, ILARIA;BETTAZZI, FRANCESCA;
2016

Abstract

This study presents the analyses of urinary biomarkers (1-OHPyr, α- and β-naphthols) of polycyclic aromatic hydrocarbons (PAHs) exposure and biomarkers of effect (i.e. blood parameters) in petroleum-refinery workers (RFs) and auto-repair workers (MCs). Exposed subjects had higher concentrations of white blood cell (WBC) count than control subjects (CN) subjects (5.31 × 103 μL−1 in exposed vs. 5.15 × 103 μL−1 in CN subjects), while the biomarker of oxidative DNA damage (8-OHdG) was significantly higher in MCs. The exposure among these two cohorts could be influenced by the ambience of the workplaces; in fact, MCs’ shops are relatively damp and enclosed workplaces in comparison with the indoor environment of refineries. PAHs in the dust samples from mechanical workshops probably originated from mixed sources (traffic exhaust and petroleum spills), while the incremental lifetime cancer risk (ILCR) for MCs showed moderate-to-low cancer risk from exposure to dust-bound PAHs. The study shows that increasing PAH exposure can be traced in MC workstations and needs to be investigated for the safety of public health.
2016
26
37
57
Kamal, Atif; Cincinelli, Alessandra; Martellini, Tania; Palchetti, Ilaria; Bettazzi, Francesca; Malik, Riffat Naseem
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1057091
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