Inflammatory T cells are thought to be central to the pathogenesis of juvenile idiopathic arthritis. In particular, recent evidence has underlined the importance of a balance between Th17 and Treg cells. Several mechanisms have come to light that control this reciprocal relationship. Moreover, it has been shown that in certain conditions, Th17 cells can shift toward a nonclassic Th1 phenotype. Anti-rheumatic biologic therapies may interfere with these mechanisms and re-establish immune tolerance.

T cell subpopulations in juvenile idiopathic arthritis and their modifications after biotherapies / Maggi, Laura; Cosmi, Lorenzo; Simonini, Gabriele; Annunziato, Francesco; Cimaz, Rolando. - In: AUTOIMMUNITY REVIEWS. - ISSN 1568-9972. - STAMPA. - (2016), pp. 0-0. [10.1016/j.autrev.2016.09.012]

T cell subpopulations in juvenile idiopathic arthritis and their modifications after biotherapies

MAGGI, LAURA;COSMI, LORENZO;SIMONINI, GABRIELE;ANNUNZIATO, FRANCESCO;CIMAZ, ROLANDO
2016

Abstract

Inflammatory T cells are thought to be central to the pathogenesis of juvenile idiopathic arthritis. In particular, recent evidence has underlined the importance of a balance between Th17 and Treg cells. Several mechanisms have come to light that control this reciprocal relationship. Moreover, it has been shown that in certain conditions, Th17 cells can shift toward a nonclassic Th1 phenotype. Anti-rheumatic biologic therapies may interfere with these mechanisms and re-establish immune tolerance.
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Goal 3: Good health and well-being
Maggi, Laura; Cosmi, Lorenzo; Simonini, Gabriele; Annunziato, Francesco; Cimaz, Rolando
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2158/1061528
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