A series of aminopyrrolic receptors were tested as anion transporters using POPC liposome model membranes. Many were found to be effective Cl- transporters and to inhibit clinical strains of Staphylococcus aureus growth in vitro. The best transporters proved effective against the methicillin-resistant Staphylococcus aureus (MRSA) strains, Mu50 and HP1173. Tris-thiourea tren-based chloride transporters were also shown to inhibit the growth of S. aureus in vitro.
Chloride anion transporters inhibit growth of methicillin-resistant: Staphylococcus aureus (MRSA) in vitro / Share, Andrew I.; Patel, Khushali; Nativi, Cristina; Cho, Eun J.; Francesconi, Oscar; Busschaert, Nathalie; Gale, Philip A.; Roelens, Stefano; Sessler, Jonathan L.. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - STAMPA. - 52:(2016), pp. 7560-7563. [10.1039/c6cc03645g]
Chloride anion transporters inhibit growth of methicillin-resistant: Staphylococcus aureus (MRSA) in vitro
NATIVI, CRISTINA;FRANCESCONI, OSCAR;ROELENS, STEFANO;
2016
Abstract
A series of aminopyrrolic receptors were tested as anion transporters using POPC liposome model membranes. Many were found to be effective Cl- transporters and to inhibit clinical strains of Staphylococcus aureus growth in vitro. The best transporters proved effective against the methicillin-resistant Staphylococcus aureus (MRSA) strains, Mu50 and HP1173. Tris-thiourea tren-based chloride transporters were also shown to inhibit the growth of S. aureus in vitro.
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