Factors affecting innate immunity and acting as inflammatory regulators, such as the nuclear peroxisome proliferator-activated receptors (PPAR) could be crucial in the pathogenesis of necrotizing enterocolitis (NEC). We hypothesized that the PPARγ agonist pioglitazone (PIO) might be effective in preventing the development of NEC and/or reducing its severity.
Peroxisome proliferator-activated receptor gamma agonist pioglitazone reduces the development of necrotizing enterocolitis in a neonatal preterm rat model / Corsini, Iuri; Polvani, Simone; Tarocchi, Mirko; Tempesti, Sara; Marroncini, Giada; Generoso, Marta; Bresci, Cecilia; Gozzini, Elena; Bianconi, Tommaso; Dani, Carlo; Galli, Andrea. - In: PEDIATRIC RESEARCH. - ISSN 1530-0447. - ELETTRONICO. - 81:(2017), pp. 364-368. [10.1038/pr.2016.214]
Peroxisome proliferator-activated receptor gamma agonist pioglitazone reduces the development of necrotizing enterocolitis in a neonatal preterm rat model
CORSINI, IURI;POLVANI, SIMONE;TAROCCHI, MIRKO;TEMPESTI, SARA;MARRONCINI, GIADA;GENEROSO, MARTA;BRESCI, CECILIA;GOZZINI, ELENA;BIANCONI, TOMMASO;DANI, CARLO;GALLI, ANDREA
2017
Abstract
Factors affecting innate immunity and acting as inflammatory regulators, such as the nuclear peroxisome proliferator-activated receptors (PPAR) could be crucial in the pathogenesis of necrotizing enterocolitis (NEC). We hypothesized that the PPARγ agonist pioglitazone (PIO) might be effective in preventing the development of NEC and/or reducing its severity.
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