Factors affecting innate immunity and acting as inflammatory regulators, such as the nuclear peroxisome proliferator-activated receptors (PPAR) could be crucial in the pathogenesis of necrotizing enterocolitis (NEC). We hypothesized that the PPARγ agonist pioglitazone (PIO) might be effective in preventing the development of NEC and/or reducing its severity.

Peroxisome proliferator-activated receptor gamma agonist pioglitazone reduces the development of necrotizing enterocolitis in a neonatal preterm rat model / Corsini, Iuri; Polvani, Simone; Tarocchi, Mirko; Tempesti, Sara; Marroncini, Giada; Generoso, Marta; Bresci, Cecilia; Gozzini, Elena; Bianconi, Tommaso; Dani, Carlo; Galli, Andrea. - In: PEDIATRIC RESEARCH. - ISSN 1530-0447. - ELETTRONICO. - 81:(2017), pp. 364-368. [10.1038/pr.2016.214]

Peroxisome proliferator-activated receptor gamma agonist pioglitazone reduces the development of necrotizing enterocolitis in a neonatal preterm rat model

CORSINI, IURI;POLVANI, SIMONE;TAROCCHI, MIRKO;TEMPESTI, SARA;MARRONCINI, GIADA;GENEROSO, MARTA;BRESCI, CECILIA;GOZZINI, ELENA;BIANCONI, TOMMASO;DANI, CARLO;GALLI, ANDREA
2017

Abstract

Factors affecting innate immunity and acting as inflammatory regulators, such as the nuclear peroxisome proliferator-activated receptors (PPAR) could be crucial in the pathogenesis of necrotizing enterocolitis (NEC). We hypothesized that the PPARγ agonist pioglitazone (PIO) might be effective in preventing the development of NEC and/or reducing its severity.
2017
81
364
368
Corsini, Iuri; Polvani, Simone; Tarocchi, Mirko; Tempesti, Sara; Marroncini, Giada; Generoso, Marta; Bresci, Cecilia; Gozzini, Elena; Bianconi, Tommas...espandi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1063506
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