. Systemic sclerosis (SSc) is characterized by excessive production of collagen and other components of the extracellular matrix (ECM) by fibroblasts. The ECM receptors, integrins and CD44 (hyaluronan receptor), play a key role in the homeostasis of connective tissue and may also have a role in the pathogenesis of fibrosis. We investigated the expression of integrins and CD44 on skin fibroblasts from patients with limited and diffuse SSc.
Distinct expression of adhesion molecules on skin fibroblasts from patients with diffuse and limited systemic sclerosis. A pilot study / Iannone, Florenzo; Matucci-Cerinic, Marco; Falappone, Paola Chiara Francesca; Guiducci, Serena; Cinelli, Marina; Distler, Oliver; Lapadula, Giovanni. - In: THE JOURNAL OF RHEUMATOLOGY. - ISSN 0315-162X. - ELETTRONICO. - 32:(2005), pp. 1893-1898.
Distinct expression of adhesion molecules on skin fibroblasts from patients with diffuse and limited systemic sclerosis. A pilot study
MATUCCI CERINIC, MARCO;GUIDUCCI, SERENA;CINELLI, MARINA;
2005
Abstract
. Systemic sclerosis (SSc) is characterized by excessive production of collagen and other components of the extracellular matrix (ECM) by fibroblasts. The ECM receptors, integrins and CD44 (hyaluronan receptor), play a key role in the homeostasis of connective tissue and may also have a role in the pathogenesis of fibrosis. We investigated the expression of integrins and CD44 on skin fibroblasts from patients with limited and diffuse SSc.
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