OBJECTIVES: The aim of this study was to determine the reference values for serum cystatin C (CysC) with a particular focus on the effect of aging. DESIGN AND METHODS: The study was performed on a consecutive series of subjects (258 men and 396 women). Laboratory parameters and a detailed personal and family medical history were collected. RESULTS: CysC showed a significant correlation with age in both sexes, which was confirmed with multivariate linear regression after adjustment for SCr (serum creatinine). Age-related reference intervals were established for cystatin C (<45 years, <0.95 mg/L and >45 years, <1.20 mg/L). CONCLUSIONS: The use of CysC reference values adjusted for age should be carefully taken into consideration.
Cystatin C reference values and aging / Ognibene, Agostino; Mannucci, Edoardo; Caldini, Anna; Terreni, Alessandro; Brogi, Marco; Bardini, Gianluca; Sposato, Iolanda; Mosconi, Valentina; Salvadori, Benedetta; Rotella, Carlo Maria; Messeri, Gianni. - In: CLINICAL BIOCHEMISTRY. - ISSN 0009-9120. - STAMPA. - 39:(2006), pp. 658-661. [10.1016/j.clinbiochem.2006.03.017]
Cystatin C reference values and aging
MANNUCCI, EDOARDO;CALDINI, ANNA;TERRENI, ALESSANDRO;BROGI, MARCO;BARDINI, GIANLUCA;SALVADORI, BENEDETTA;ROTELLA, CARLO MARIA;
2006
Abstract
OBJECTIVES: The aim of this study was to determine the reference values for serum cystatin C (CysC) with a particular focus on the effect of aging. DESIGN AND METHODS: The study was performed on a consecutive series of subjects (258 men and 396 women). Laboratory parameters and a detailed personal and family medical history were collected. RESULTS: CysC showed a significant correlation with age in both sexes, which was confirmed with multivariate linear regression after adjustment for SCr (serum creatinine). Age-related reference intervals were established for cystatin C (<45 years, <0.95 mg/L and >45 years, <1.20 mg/L). CONCLUSIONS: The use of CysC reference values adjusted for age should be carefully taken into consideration.
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