Hepatic stellate cells (HSC) transdifferentiation into collagen-producing myofibroblasts is a key event in hepatic fibrogenesis, but the transcriptional network that controls the acquisition of the activated phenotype is still poorly understood. In this study, we explored whether the nuclear receptor Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUP-TFII) is involved in HSC activation and in the multifunctional role of these cells during the response to liver injury.

The orphan nuclear receptor COUP-TFII coordinates hypoxia-independent proangiogenic responses in hepatic stellate cells / Ceni, Elisabetta; Mello, Tommaso; Polvani, Simone; Vasseur Cognet, Mireille; Tarocchi, Mirko; Tempesti, Sara; Cavalieri, Duccio; Beltrame, Luca; Marroncini, Giada; Pinzani, Massimo; Milani, Stefano; Galli, Andrea. - In: JOURNAL OF HEPATOLOGY. - ISSN 0168-8278. - ELETTRONICO. - 66:(2017), pp. 754-764. [10.1016/j.jhep.2016.11.003]

The orphan nuclear receptor COUP-TFII coordinates hypoxia-independent proangiogenic responses in hepatic stellate cells

CENI, ELISABETTA;MELLO, TOMMASO;POLVANI, SIMONE;TAROCCHI, MIRKO;TEMPESTI, SARA;CAVALIERI, DUCCIO;BELTRAME, LUCA;MARRONCINI, GIADA;PINZANI, MASSIMO;MILANI, STEFANO;GALLI, ANDREA
2017

Abstract

Hepatic stellate cells (HSC) transdifferentiation into collagen-producing myofibroblasts is a key event in hepatic fibrogenesis, but the transcriptional network that controls the acquisition of the activated phenotype is still poorly understood. In this study, we explored whether the nuclear receptor Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUP-TFII) is involved in HSC activation and in the multifunctional role of these cells during the response to liver injury.
2017
66
754
764
Ceni, Elisabetta; Mello, Tommaso; Polvani, Simone; Vasseur Cognet, Mireille; Tarocchi, Mirko; Tempesti, Sara; Cavalieri, Duccio; Beltrame, Luca; Marro...espandi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1064183
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