The association between inflammation and cancer has been pointed out in epidemiological and clinical studies, revealing how chronic inflammation may contribute to carcinogenesis in various malignancies. However, the molecular events leading to malignant transformation in a chronically inflamed environment are not fully understood. In urothelial carcinoma of the urinary bladder, inflammation plays a dual role. On the one hand, chronic inflammation is a well-established risk factor for the development of bladder cancer (BC), as seen in Schistosoma haematobium infection. On the other, intravesical therapy by bacillus Calmette-Guérin (BCG), which induces inflammation, offers protection against cancer recurrence. The large variety of pro-inflammatory mediators expressed by BC and immune cells binds to specific receptors which control signalling pathways. These activate transcription of a plethora of downstream factors. This review summarizes recent data regarding inflammation and urothelial carcinoma, with special emphasis on the role the inflammatory response plays in BC recurrence risk and progression.

Chronic inflammation in urothelial bladder cancer / Nesi, Gabriella; Nobili, Stefania; Cai, Tommaso; Caini, Saverio; Santi, Raffaella. - In: VIRCHOWS ARCHIV. - ISSN 0945-6317. - STAMPA. - 467:(2015), pp. 623-633. [10.1007/s00428-015-1820-x]

Chronic inflammation in urothelial bladder cancer

Nesi, Gabriella;Nobili, Stefania;Santi, Raffaella
2015

Abstract

The association between inflammation and cancer has been pointed out in epidemiological and clinical studies, revealing how chronic inflammation may contribute to carcinogenesis in various malignancies. However, the molecular events leading to malignant transformation in a chronically inflamed environment are not fully understood. In urothelial carcinoma of the urinary bladder, inflammation plays a dual role. On the one hand, chronic inflammation is a well-established risk factor for the development of bladder cancer (BC), as seen in Schistosoma haematobium infection. On the other, intravesical therapy by bacillus Calmette-Guérin (BCG), which induces inflammation, offers protection against cancer recurrence. The large variety of pro-inflammatory mediators expressed by BC and immune cells binds to specific receptors which control signalling pathways. These activate transcription of a plethora of downstream factors. This review summarizes recent data regarding inflammation and urothelial carcinoma, with special emphasis on the role the inflammatory response plays in BC recurrence risk and progression.
2015
467
623
633
Nesi, Gabriella; Nobili, Stefania; Cai, Tommaso; Caini, Saverio; Santi, Raffaella
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1065959
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