Persistent dry cough is a well known unwanted effect of Angiotensin-Converting Enzyme inhibitors (ACE-i). Animal studies have shown that the ACE-i zofenopril has a less tussigenic effect compared to the widely used ACE-i ramipril. The aim of this study was to compare cough sensitivity to inhaled tussigens, as well as spontaneous cough in response to the administration of zofenopril and ramipril in healthy volunteers; pharmacokinetic (PK) data of both zofenopril and ramipril, as well as their respective active forms, zofenoprilat and ramiprilat, was also collected.

A crossover randomized comparative study of zofenopril and ramipril on cough reflex and airway inflammation in healthy volunteers / Lavorini, Federico; Chellini, Elisa; Innocenti, Margherita; Campi, Giacomo; Egan, Colin Gerard; Mogavero, Selene; Fontana, Giovanni A. - In: COUGH. - ISSN 1745-9974. - ELETTRONICO. - 10:(2014), pp. 0-0. [10.1186/s12997-014-0007-5]

A crossover randomized comparative study of zofenopril and ramipril on cough reflex and airway inflammation in healthy volunteers

LAVORINI, FEDERICO;CHELLINI, ELISA;INNOCENTI, MARGHERITA;FONTANA, GIOVANNI
2014

Abstract

Persistent dry cough is a well known unwanted effect of Angiotensin-Converting Enzyme inhibitors (ACE-i). Animal studies have shown that the ACE-i zofenopril has a less tussigenic effect compared to the widely used ACE-i ramipril. The aim of this study was to compare cough sensitivity to inhaled tussigens, as well as spontaneous cough in response to the administration of zofenopril and ramipril in healthy volunteers; pharmacokinetic (PK) data of both zofenopril and ramipril, as well as their respective active forms, zofenoprilat and ramiprilat, was also collected.
2014
10
0
0
Lavorini, Federico; Chellini, Elisa; Innocenti, Margherita; Campi, Giacomo; Egan, Colin Gerard; Mogavero, Selene; Fontana, Giovanni A
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1066279
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