Tuberculosis still represents a big global public health challenge. The diagnosis of tuberculosis and the differentiation between active and latent tuberculosis remain difficult, particularly in childhood, because of the lack of a gold standard test for diagnosis. In the last decade, novel diagnostic assays have been developed. Among immunologic tests, new assays based on the measurement of different cytokines released by specific T cells in response to Mycobacterium tuberculosis antigens, other than INF-γ, have been investigated. Promising results rely on nucleic acid amplification techniques, also able to detect drugs resistance. Innovative research fields studied the modifications of CD27 expression in T cells as well as different host gene expression in response to M. tuberculosis. Further studies are needed to assess the diagnostic value and the accuracy of these new assays.

What steps do we need to take to improve diagnosis of tuberculosis in children? / Venturini, Elisabetta; Remaschi, Giulia; Berti, Elettra; Montagnani, Carlotta; Galli, Luisa; De Martino, Maurizio; Chiappini, Elena. - In: EXPERT REVIEW OF ANTI-INFECTIVE THERAPY. - ISSN 1478-7210. - STAMPA. - 13:(2015), pp. 907-922. [10.1586/14787210.2015.1040764]

What steps do we need to take to improve diagnosis of tuberculosis in children?

GALLI, LUISA;DE MARTINO, MAURIZIO;CHIAPPINI, ELENA
2015

Abstract

Tuberculosis still represents a big global public health challenge. The diagnosis of tuberculosis and the differentiation between active and latent tuberculosis remain difficult, particularly in childhood, because of the lack of a gold standard test for diagnosis. In the last decade, novel diagnostic assays have been developed. Among immunologic tests, new assays based on the measurement of different cytokines released by specific T cells in response to Mycobacterium tuberculosis antigens, other than INF-γ, have been investigated. Promising results rely on nucleic acid amplification techniques, also able to detect drugs resistance. Innovative research fields studied the modifications of CD27 expression in T cells as well as different host gene expression in response to M. tuberculosis. Further studies are needed to assess the diagnostic value and the accuracy of these new assays.
2015
13
907
922
Venturini, Elisabetta; Remaschi, Giulia; Berti, Elettra; Montagnani, Carlotta; Galli, Luisa; De Martino, Maurizio; Chiappini, Elena
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1071707
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