New linear and cyclic chalcogen-containing compounds have been synthesized exploiting the reactivity of bis(trimethylsilyl)selenide with strained heterocycles. A simple and efficient procedure allowed a selective access to β-functionalized selenides, diselenides, and dithiaselenepanes undermild conditions. Antioxidant catalytic activity of these compounds was investigated in the reaction of hydrogen peroxidewith dithiothreitol (DTTred). According to this assay, some of the synthesized structures exhibited a remarkable glutathione peroxidase (GPx)-like activity.

Novel sulfur and selenium containing antioxidants: synthesis and evaluation of their GPx-like activity / Tanini, Damiano; D’Esopo, Veronica; Chen, Dan; Barchielli, Giulia; Capperucci, Antonella. - In: PHOSPHORUS, SULFUR, AND SILICON AND THE RELATED ELEMENTS. - ISSN 1563-5325. - ELETTRONICO. - 192:(2017), pp. 166-168. [DOI: 10.1080/10426507.2016.1252365]

Novel sulfur and selenium containing antioxidants: synthesis and evaluation of their GPx-like activity

TANINI, DAMIANO;CAPPERUCCI, ANTONELLA
2017

Abstract

New linear and cyclic chalcogen-containing compounds have been synthesized exploiting the reactivity of bis(trimethylsilyl)selenide with strained heterocycles. A simple and efficient procedure allowed a selective access to β-functionalized selenides, diselenides, and dithiaselenepanes undermild conditions. Antioxidant catalytic activity of these compounds was investigated in the reaction of hydrogen peroxidewith dithiothreitol (DTTred). According to this assay, some of the synthesized structures exhibited a remarkable glutathione peroxidase (GPx)-like activity.
2017
192
166
168
Tanini, Damiano; D’Esopo, Veronica; Chen, Dan; Barchielli, Giulia; Capperucci, Antonella
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1071745
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