Characterization of the behavioural phenotype of H4R-deficient mice assessed a functional role of neuronal H4R and highlighted the importance of its integrity in the histaminergic regulation of important neurophysiological functions, including pain sensitivity and anxiety. Since the identification of H4R, several ligands activating this receptor have been described and more compounds are in development. Targeting neuronal H4R with selective agonists might be a clinical relevant therapeutic approach to be exploited to relieve neuropathic pain and to better manage anxiety and anxiety-related disorders.
Central neuronal functions of histamine H4 receptors / Sanna, Maria Domenica; Galeotti, Nicoletta. - In: ONCOTARGET. - ISSN 1949-2553. - STAMPA. - 8:(2017), pp. 12556-12557. [10.18632/oncotarget.15289]
Central neuronal functions of histamine H4 receptors
SANNA, MARIA DOMENICA;GALEOTTI, NICOLETTA
2017
Abstract
Characterization of the behavioural phenotype of H4R-deficient mice assessed a functional role of neuronal H4R and highlighted the importance of its integrity in the histaminergic regulation of important neurophysiological functions, including pain sensitivity and anxiety. Since the identification of H4R, several ligands activating this receptor have been described and more compounds are in development. Targeting neuronal H4R with selective agonists might be a clinical relevant therapeutic approach to be exploited to relieve neuropathic pain and to better manage anxiety and anxiety-related disorders.File | Dimensione | Formato | |
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