A series of N-alkanol-N-cyclohexanolamine arylesters were designed and synthesized. The new compounds were tested on the K562/DOX cell line by three different tests. They behave as P-gp-dependent multidrug resistance (MDR) reversers. The chemical stability of the ester function of the compounds was evaluated. A compound results interesting lead for the development of new P-gp modulators

N-alkanol-N-cyclohexanol amine aryl esters: Multidrug resistance (MDR) reversing agents with high potency and efficacy / Teodori, Elisabetta; Dei, Silvia; Coronnello, Marcella; Floriddia, Elisa; Bartolucci, Gianluca; Manetti, Dina; Romanelli, Maria Novella; Santo Domingo Porqueras, Diego; Salerno, Milena. - In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0223-5234. - ELETTRONICO. - 127:(2017), pp. 586-598. [10.1016/j.ejmech.2017.01.019]

N-alkanol-N-cyclohexanol amine aryl esters: Multidrug resistance (MDR) reversing agents with high potency and efficacy

TEODORI, ELISABETTA;DEI, SILVIA;CORONNELLO, MARCELLA MARIA;FLORIDDIA, ELISA;BARTOLUCCI, GIAN LUCA;MANETTI, DINA;ROMANELLI, MARIA NOVELLA;
2017

Abstract

A series of N-alkanol-N-cyclohexanolamine arylesters were designed and synthesized. The new compounds were tested on the K562/DOX cell line by three different tests. They behave as P-gp-dependent multidrug resistance (MDR) reversers. The chemical stability of the ester function of the compounds was evaluated. A compound results interesting lead for the development of new P-gp modulators
2017
127
586
598
Teodori, Elisabetta; Dei, Silvia; Coronnello, Marcella; Floriddia, Elisa; Bartolucci, Gianluca; Manetti, Dina; Romanelli, Maria Novella; Santo Domingo...espandi
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S0223523417300272-main.pdf

Accesso chiuso

Descrizione: Articolo principale
Tipologia: Pdf editoriale (Version of record)
Licenza: Tutti i diritti riservati
Dimensione 926.56 kB
Formato Adobe PDF
926.56 kB Adobe PDF   Richiedi una copia

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1076700
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 10
  • ???jsp.display-item.citation.isi??? 10
social impact