A series of N-alkanol-N-cyclohexanolamine arylesters were designed and synthesized. The new compounds were tested on the K562/DOX cell line by three different tests. They behave as P-gp-dependent multidrug resistance (MDR) reversers. The chemical stability of the ester function of the compounds was evaluated. A compound results interesting lead for the development of new P-gp modulators
N-alkanol-N-cyclohexanol amine aryl esters: Multidrug resistance (MDR) reversing agents with high potency and efficacy / Teodori, Elisabetta; Dei, Silvia; Coronnello, Marcella; Floriddia, Elisa; Bartolucci, Gianluca; Manetti, Dina; Romanelli, Maria Novella; Santo Domingo Porqueras, Diego; Salerno, Milena. - In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0223-5234. - ELETTRONICO. - 127:(2017), pp. 586-598. [10.1016/j.ejmech.2017.01.019]
N-alkanol-N-cyclohexanol amine aryl esters: Multidrug resistance (MDR) reversing agents with high potency and efficacy
TEODORI, ELISABETTA;DEI, SILVIA;CORONNELLO, MARCELLA MARIA;FLORIDDIA, ELISA;BARTOLUCCI, GIAN LUCA;MANETTI, DINA;ROMANELLI, MARIA NOVELLA;
2017
Abstract
A series of N-alkanol-N-cyclohexanolamine arylesters were designed and synthesized. The new compounds were tested on the K562/DOX cell line by three different tests. They behave as P-gp-dependent multidrug resistance (MDR) reversers. The chemical stability of the ester function of the compounds was evaluated. A compound results interesting lead for the development of new P-gp modulators
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