Granulomatous lung diseases present different and often uncertain causes, but inflammatory and immunological disorders are common. Many markers are proposed to study the evolution of those disorders as ACE, Neopterin (N), β2microglobulin (β2), PIIIP. We want to revalue those factors considering the kind and the stage of the diseases. We studied 28 patients with histologically proven sarcoidosis (S) and 16 patients affected by interstitial lung fibrosis of various origin (LF). ACE, N, β2, PIIIP, IL2, IL6 and TNFα are determined in the sera. In the brochoalveolar fluids (BALf) IL2, IL6 and TNFα are dosed. A good correlation (p< .01) is obtained between seric concentrations of N and those of ACE, β2 in both sarcoidosis patients and LF subjects with an higher significance in S. No correlations are showed between cytokines concentration in BALf and concentrations of cytokines, ACE, β2, PIIIP in the sera. In sarcoidosis patients IL6 and TNFα BALf concentrations are correlated with lymphocyte per cent and CD4/CD8 in BALf. Seric determination of ACE and N seems to be useful at least in sarcoidosis, in evaluation of the tendency of the evolution of the pathology. IL6 and TNFα determination in BALf seems to be correlate with inflammatory process.

Malattie granulomatose del polmone. Studio sull'utilità della determinazione nel siero e nel balf di vari markers / Arcangeli, Giulio; Calabro, S.; Montalti, M.; Boccalon, P.; Cupelli, V.. - In: GIORNALE ITALIANO DI MEDICINA DEL LAVORO ED ERGONOMIA. - ISSN 1592-7830. - STAMPA. - 28:(2006), pp. 365-366.

Malattie granulomatose del polmone. Studio sull'utilità della determinazione nel siero e nel balf di vari markers

ARCANGELI, GIULIO;CUPELLI, VINCENZO
2006

Abstract

Granulomatous lung diseases present different and often uncertain causes, but inflammatory and immunological disorders are common. Many markers are proposed to study the evolution of those disorders as ACE, Neopterin (N), β2microglobulin (β2), PIIIP. We want to revalue those factors considering the kind and the stage of the diseases. We studied 28 patients with histologically proven sarcoidosis (S) and 16 patients affected by interstitial lung fibrosis of various origin (LF). ACE, N, β2, PIIIP, IL2, IL6 and TNFα are determined in the sera. In the brochoalveolar fluids (BALf) IL2, IL6 and TNFα are dosed. A good correlation (p< .01) is obtained between seric concentrations of N and those of ACE, β2 in both sarcoidosis patients and LF subjects with an higher significance in S. No correlations are showed between cytokines concentration in BALf and concentrations of cytokines, ACE, β2, PIIIP in the sera. In sarcoidosis patients IL6 and TNFα BALf concentrations are correlated with lymphocyte per cent and CD4/CD8 in BALf. Seric determination of ACE and N seems to be useful at least in sarcoidosis, in evaluation of the tendency of the evolution of the pathology. IL6 and TNFα determination in BALf seems to be correlate with inflammatory process.
2006
28
365
366
Arcangeli, Giulio; Calabro, S.; Montalti, M.; Boccalon, P.; Cupelli, V.
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1077490
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