Chromosomal instability (CIN) is the most common form of genomic instability, which promotes hepatocellular carcinoma (HCC) progression by enhancing tumour heterogeneity, drug resistance and immunity escape. CIN per se is an important factor of DNA damage, sustaining structural chromosome abnormalities but the underlying mechanisms are unknown.

CHK2 overexpression and mislocalisation within mitotic structures enhances chromosomal instability and hepatocellular carcinoma progression / Carloni, Vinicio; Lulli, Matteo; Madiai, Stefania; Mello, Tommaso; Hall, Andrew; Luong, Tu Vinh; Pinzani, Massimo; Rombouts, Krista; Galli, Andrea. - In: GUT. - ISSN 0017-5749. - ELETTRONICO. - 67:(2017), pp. 348-361. [10.1136/gutjnl-2016-313114]

CHK2 overexpression and mislocalisation within mitotic structures enhances chromosomal instability and hepatocellular carcinoma progression

CARLONI, VINICIO
;
LULLI, MATTEO;MELLO, TOMMASO;GALLI, ANDREA
2017

Abstract

Chromosomal instability (CIN) is the most common form of genomic instability, which promotes hepatocellular carcinoma (HCC) progression by enhancing tumour heterogeneity, drug resistance and immunity escape. CIN per se is an important factor of DNA damage, sustaining structural chromosome abnormalities but the underlying mechanisms are unknown.
2017
GUT
67
348
361
Carloni, Vinicio; Lulli, Matteo; Madiai, Stefania; Mello, Tommaso; Hall, Andrew; Luong, Tu Vinh; Pinzani, Massimo; Rombouts, Krista; Galli, Andrea
File in questo prodotto:
File Dimensione Formato  
Carloni et al 2017.pdf

Accesso chiuso

Tipologia: Pdf editoriale (Version of record)
Licenza: Tutti i diritti riservati
Dimensione 7.32 MB
Formato Adobe PDF
7.32 MB Adobe PDF   Richiedi una copia
2158-1080156_preprint.pdf

accesso aperto

Tipologia: Preprint (Submitted version)
Licenza: Open Access
Dimensione 3.65 MB
Formato Adobe PDF
3.65 MB Adobe PDF

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1080156
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 37
  • ???jsp.display-item.citation.isi??? 32
social impact