Chromosomal instability (CIN) is the most common form of genomic instability, which promotes hepatocellular carcinoma (HCC) progression by enhancing tumour heterogeneity, drug resistance and immunity escape. CIN per se is an important factor of DNA damage, sustaining structural chromosome abnormalities but the underlying mechanisms are unknown.
CHK2 overexpression and mislocalisation within mitotic structures enhances chromosomal instability and hepatocellular carcinoma progression / Carloni, Vinicio; Lulli, Matteo; Madiai, Stefania; Mello, Tommaso; Hall, Andrew; Luong, Tu Vinh; Pinzani, Massimo; Rombouts, Krista; Galli, Andrea. - In: GUT. - ISSN 0017-5749. - ELETTRONICO. - 67:(2017), pp. 348-361. [10.1136/gutjnl-2016-313114]
CHK2 overexpression and mislocalisation within mitotic structures enhances chromosomal instability and hepatocellular carcinoma progression
CARLONI, VINICIO
;LULLI, MATTEO;MELLO, TOMMASO;GALLI, ANDREA
2017
Abstract
Chromosomal instability (CIN) is the most common form of genomic instability, which promotes hepatocellular carcinoma (HCC) progression by enhancing tumour heterogeneity, drug resistance and immunity escape. CIN per se is an important factor of DNA damage, sustaining structural chromosome abnormalities but the underlying mechanisms are unknown.
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