According to the literature, the APP Ala713Thr mutation is associated with Alzheimer's disease and cerebral amyloid angiopathy. We describe a case of dementia clinically compatible with frontotemporal dementia in an APP Ala713Thr mutation carrier in which both [18F]Florbetapir PET uptake and Aβ1-42 cerebrospinal fluid levels were normal. Further evidences are required to establish if this association is only incidental.

Low Florbetapir PET Uptake and Normal Aβ1-42 Cerebrospinal Fluid in an APP Ala713Thr Mutation Carrier / Lombardi, Gemma; Berti, Valentina; Tedde, Andrea; Bagnoli, Silvia; Piaceri, Irene; Polito, Cristina; Lucidi, Giulia; Ferrari, Camilla; Ginestroni, Andrea; Moretti, Marco; Pupi, Alberto; Nacmias, Benedetta; Sorbi, Sandro. - In: JOURNAL OF ALZHEIMER'S DISEASE. - ISSN 1387-2877. - ELETTRONICO. - 57:(2017), pp. 697-703. [10.3233/JAD-161170]

Low Florbetapir PET Uptake and Normal Aβ1-42 Cerebrospinal Fluid in an APP Ala713Thr Mutation Carrier

LOMBARDI, GEMMA;BERTI, VALENTINA;TEDDE, ANDREA;BAGNOLI, SILVIA;PIACERI, IRENE;POLITO, CRISTINA;LUCIDI, GIULIA;FERRARI, CAMILLA;GINESTRONI, ANDREA;MORETTI, MARCO;PUPI, ALBERTO;NACMIAS, BENEDETTA;SORBI, SANDRO
2017

Abstract

According to the literature, the APP Ala713Thr mutation is associated with Alzheimer's disease and cerebral amyloid angiopathy. We describe a case of dementia clinically compatible with frontotemporal dementia in an APP Ala713Thr mutation carrier in which both [18F]Florbetapir PET uptake and Aβ1-42 cerebrospinal fluid levels were normal. Further evidences are required to establish if this association is only incidental.
2017
57
697
703
Lombardi, Gemma; Berti, Valentina; Tedde, Andrea; Bagnoli, Silvia; Piaceri, Irene; Polito, Cristina; Lucidi, Giulia; Ferrari, Camilla; Ginestroni, Andrea; Moretti, Marco; Pupi, Alberto; Nacmias, Benedetta; Sorbi, Sandro
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1082872
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