The ability of a rigid α-Tn mimetic (compound 1) to activate murine invariant natural killer T (iNKT) and human natural killer (NK) cells, two subsets of lymphocytes involved in cancer immunesurveillance, was investigated. For this purpose, the mimetic 1 was properly conjugated to a stearic acid containing glycerol-based phospholipid (compound 5) to be presented, in the context of the conserved non polymorphic major histocompatibility complex class I-like molecules (CD1d), to iNKT cells. On the contrary, the mimetic 1 was conjugated to a multivalent peptide-based scaffold (compound 6) to induce NK cell activation.
Immunological characterization of a rigid α-Tn mimetic on murine iNKT and human NK cells / Fallarini, Silvia; Brittoli, Alvaro; Fiore, Michele; Lombardi, Grazia; Renaudet, Olivier; Richichi, Barbara; Nativi, Cristina. - In: GLYCOCONJUGATE JOURNAL. - ISSN 0282-0080. - ELETTRONICO. - 34:(2017), pp. 553-562. [10.1007/s10719-017-9775-6]
Immunological characterization of a rigid α-Tn mimetic on murine iNKT and human NK cells
RICHICHI, BARBARA
;NATIVI, CRISTINA
2017
Abstract
The ability of a rigid α-Tn mimetic (compound 1) to activate murine invariant natural killer T (iNKT) and human natural killer (NK) cells, two subsets of lymphocytes involved in cancer immunesurveillance, was investigated. For this purpose, the mimetic 1 was properly conjugated to a stearic acid containing glycerol-based phospholipid (compound 5) to be presented, in the context of the conserved non polymorphic major histocompatibility complex class I-like molecules (CD1d), to iNKT cells. On the contrary, the mimetic 1 was conjugated to a multivalent peptide-based scaffold (compound 6) to induce NK cell activation.File | Dimensione | Formato | |
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