T-cell activation in two cases of Stevens-Johnson syndrome after receiving amoxicillin-clavulanic acid

Stevens-Johnson syndrome (SJS) is a rare life-threatening condition attributed almost exclusively to drug exposure (1). The main etiologic factor for SJS is treatment with drugs, primarily sulfonamides and anticonvulsants, followed by penicillins and non-steroidal anti-inflammatory drugs (1). Among penicillins, amoxicillin/clavulanic acid (AMX/CLV), despite generally being a well-tolerated antimicrobial, has been reported as a risk factor for SJS in adults and children in several publications (2, 3).