Hypersensitivity reactions to tramadol are rare and the drug is commonly considered safe. Here, we report the first case of anaphylaxis to tramadol in a child. We point out the difficulty in reaching a confident diagnosis when testing opioid alkaloid drugs with histamine-releasing properties. Additionally, we showed the importance of a well-performed allergy work-up, especially when testing drugs with low experience and when standardized concentrations have not been tested. Moreover, this case provides insight into the possibility of severe reactions, and even anaphylaxis, to tramadol.

Anaphylaxis to Intravenous Tramadol in a Child / Mori, Francesca; Barni, Simona; Manfredi, Mariangela; Sarti, Lucrezia; Pecorari, Lisa; Pucci, Neri; Novembre, Elio. - In: PHARMACOLOGY. - ISSN 0031-7012. - ELETTRONICO. - 96:(2015), pp. 256-258. [10.1159/000441005]

Anaphylaxis to Intravenous Tramadol in a Child

MORI, FRANCESCA;BARNI, SIMONA;SARTI, LUCREZIA;PUCCI, NERI;NOVEMBRE, ELIO MASSIMO
2015

Abstract

Hypersensitivity reactions to tramadol are rare and the drug is commonly considered safe. Here, we report the first case of anaphylaxis to tramadol in a child. We point out the difficulty in reaching a confident diagnosis when testing opioid alkaloid drugs with histamine-releasing properties. Additionally, we showed the importance of a well-performed allergy work-up, especially when testing drugs with low experience and when standardized concentrations have not been tested. Moreover, this case provides insight into the possibility of severe reactions, and even anaphylaxis, to tramadol.
2015
96
256
258
Mori, Francesca; Barni, Simona; Manfredi, Mariangela; Sarti, Lucrezia; Pecorari, Lisa; Pucci, Neri; Novembre, Elio
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1089338
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