Drug-induced liver injury is one of the most serious adverse drug reactions and the most frequent reason for restriction of indications or withdrawal of drugs. Some nonsteroidal anti-inflammatory drugs (NSAIDs) were withdrawn from the market because of serious hepatotoxicity. We estimated the risk of acute and serious liver injury associated with the use of nimesulide and other NSAIDs, with a prevalence of use greater than or equal to 5%.

Risk of acute and serious liver injury associated to nimesulide and other NSAIDs: data from drug-induced liver injury case-control study in Italy / Donati, Monia; Conforti, Anita; Lenti, Maria Carmela; Capuano, Annalisa; Bortolami, Oscar; Motola, Domenico; Moretti, Ugo; Vannacci, Alfredo; Rafaniello, Concetta; Vaccheri, Alberto; Arzenton, Elena; Bonaiuti, Roberto; Sportiello, Liberata; Leone, Roberto. - In: BJCP. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. - ISSN 1365-2125. - ELETTRONICO. - 82:(2016), pp. 238-248. [10.1111/bcp.12938]

Risk of acute and serious liver injury associated to nimesulide and other NSAIDs: data from drug-induced liver injury case-control study in Italy

LENTI, MARIA CARMELA;VANNACCI, ALFREDO;BONAIUTI, ROBERTO;
2016

Abstract

Drug-induced liver injury is one of the most serious adverse drug reactions and the most frequent reason for restriction of indications or withdrawal of drugs. Some nonsteroidal anti-inflammatory drugs (NSAIDs) were withdrawn from the market because of serious hepatotoxicity. We estimated the risk of acute and serious liver injury associated with the use of nimesulide and other NSAIDs, with a prevalence of use greater than or equal to 5%.
2016
82
238
248
Donati, Monia; Conforti, Anita; Lenti, Maria Carmela; Capuano, Annalisa; Bortolami, Oscar; Motola, Domenico; Moretti, Ugo; Vannacci, Alfredo; Rafaniello, Concetta; Vaccheri, Alberto; Arzenton, Elena; Bonaiuti, Roberto; Sportiello, Liberata; Leone, Roberto
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1089558
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