Drug-induced liver injury is one of the most serious adverse drug reactions and the most frequent reason for restriction of indications or withdrawal of drugs. Some nonsteroidal anti-inflammatory drugs (NSAIDs) were withdrawn from the market because of serious hepatotoxicity. We estimated the risk of acute and serious liver injury associated with the use of nimesulide and other NSAIDs, with a prevalence of use greater than or equal to 5%.
Risk of acute and serious liver injury associated to nimesulide and other NSAIDs: data from drug-induced liver injury case-control study in Italy / Donati, Monia; Conforti, Anita; Lenti, Maria Carmela; Capuano, Annalisa; Bortolami, Oscar; Motola, Domenico; Moretti, Ugo; Vannacci, Alfredo; Rafaniello, Concetta; Vaccheri, Alberto; Arzenton, Elena; Bonaiuti, Roberto; Sportiello, Liberata; Leone, Roberto. - In: BJCP. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. - ISSN 1365-2125. - ELETTRONICO. - 82:(2016), pp. 238-248. [10.1111/bcp.12938]
Risk of acute and serious liver injury associated to nimesulide and other NSAIDs: data from drug-induced liver injury case-control study in Italy
LENTI, MARIA CARMELA;VANNACCI, ALFREDO;BONAIUTI, ROBERTO;
2016
Abstract
Drug-induced liver injury is one of the most serious adverse drug reactions and the most frequent reason for restriction of indications or withdrawal of drugs. Some nonsteroidal anti-inflammatory drugs (NSAIDs) were withdrawn from the market because of serious hepatotoxicity. We estimated the risk of acute and serious liver injury associated with the use of nimesulide and other NSAIDs, with a prevalence of use greater than or equal to 5%.
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