The novel signal peptide SLPmod was used for the secretion of murine interleukin-12 (mIL-12) by Lactococcus lactis. A >4-fold increase in secretion was observed when SLPmod was used instead of the Usp45-derived secretion signal. Oral delivery of this cytokine using the autoinducible host L. lactis FI5876 utilizing SLPmod resulted in a significant increase in mIL-12 plasma levels in mice.
Enhanced secretion of biologically active murine interleukin-12 by lactococcus lactis / Fernandez, Antonio; Horn, Nikki; Wegmann, Udo; Nicoletti, Claudio; Gasson, Michael J.; Narbad, Arjan. - In: APPLIED AND ENVIRONMENTAL MICROBIOLOGY. - ISSN 0099-2240. - STAMPA. - 75:(2009), pp. 869-871. [10.1128/AEM.01728-08]
Enhanced secretion of biologically active murine interleukin-12 by lactococcus lactis
NICOLETTI, CLAUDIO;
2009
Abstract
The novel signal peptide SLPmod was used for the secretion of murine interleukin-12 (mIL-12) by Lactococcus lactis. A >4-fold increase in secretion was observed when SLPmod was used instead of the Usp45-derived secretion signal. Oral delivery of this cytokine using the autoinducible host L. lactis FI5876 utilizing SLPmod resulted in a significant increase in mIL-12 plasma levels in mice.
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