Their intense optical absorbance in the near-infrared window and chemical versatility make gold nanorods attractive for biomedical applications, such as photothermal therapies and photoacoustic imaging. However, their limited photostability remains a drawback of practical concern. In fact, when gold nanorods are irradiated with nanosecond laser pulses in resonance with their plasmon oscillations, there may occur reshaping into spherical particles or even fragmentation at higher optical fluences, which cause substantial modifications of their optical features with a loss of photoacoustic conversion efficiency. In this contribution, we focus on how the gold nanorods photostability is affected when these particles are modified for cellular uptake, by investigating their stability and photoacoustic conversion efficiency under near infrared pulsed irradiation at different laser fluences.
The influence of cellular uptake on gold nanorods photostability and photoacoustic conversion efficiency / Cavigli, Lucia; Ratto, Fulvio; Tatini, Francesca; Matteini, Paolo; Cini, Alberto; Giovannelli, Ilaria; DE ANGELIS, Marella; Rossi, Francesca; Centi, Sonia; Pini, Roberto. - In: PROGRESS IN BIOMEDICAL OPTICS AND IMAGING. - ISSN 1605-7422. - STAMPA. - 9323:(2015), pp. 932346-932348. (Intervento presentato al convegno Photons Plus Ultrasound: Imaging and Sensing 2015 tenutosi a usa nel 2015) [10.1117/12.2077632].
The influence of cellular uptake on gold nanorods photostability and photoacoustic conversion efficiency
Cavigli, Lucia;Tatini, Francesca;Matteini, Paolo;Cini, Alberto;De Angelis, Marella;Centi, Sonia;Pini, Roberto
2015
Abstract
Their intense optical absorbance in the near-infrared window and chemical versatility make gold nanorods attractive for biomedical applications, such as photothermal therapies and photoacoustic imaging. However, their limited photostability remains a drawback of practical concern. In fact, when gold nanorods are irradiated with nanosecond laser pulses in resonance with their plasmon oscillations, there may occur reshaping into spherical particles or even fragmentation at higher optical fluences, which cause substantial modifications of their optical features with a loss of photoacoustic conversion efficiency. In this contribution, we focus on how the gold nanorods photostability is affected when these particles are modified for cellular uptake, by investigating their stability and photoacoustic conversion efficiency under near infrared pulsed irradiation at different laser fluences.
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