The paratrigeminal respiratory group (pTRG) is responsible for the respiratory pattern generation in the lamprey. The role of ATP and astrocytes, known to control respiratory activity in mammals, was investigated in the lamprey respiratory network. ATP microinjected into the pTRG induces a biphasic response consisting of marked increases in respiratory frequency mediated by P2X receptors followed by a decrease in the respiratory motor output due to the ATP metabolite adenosine. We provide evidence that astrocytes are involved in the genesis of the normal respiratory pattern, ATP-induced responses and acidification-induced increases of the respiratory activity. The function of astrocytes in rhythmic networks appears to be phylogenetically conserved.
ATP and astrocytes play a prominent role in the control of the respiratory pattern generator in the lamprey / Cinelli, Elenia; Iovino, Ludovica; Mutolo, Donatella. - In: THE JOURNAL OF PHYSIOLOGY. - ISSN 0022-3751. - ELETTRONICO. - 595:(2017), pp. 7063-7079. [10.1113/JP274749]
ATP and astrocytes play a prominent role in the control of the respiratory pattern generator in the lamprey
Cinelli, Elenia;IOVINO, LUDOVICA;Mutolo, Donatella
2017
Abstract
The paratrigeminal respiratory group (pTRG) is responsible for the respiratory pattern generation in the lamprey. The role of ATP and astrocytes, known to control respiratory activity in mammals, was investigated in the lamprey respiratory network. ATP microinjected into the pTRG induces a biphasic response consisting of marked increases in respiratory frequency mediated by P2X receptors followed by a decrease in the respiratory motor output due to the ATP metabolite adenosine. We provide evidence that astrocytes are involved in the genesis of the normal respiratory pattern, ATP-induced responses and acidification-induced increases of the respiratory activity. The function of astrocytes in rhythmic networks appears to be phylogenetically conserved.File | Dimensione | Formato | |
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