On the SERS quantitative determination of organic dyes

The use of surface‐enhanced Raman scattering methods for the quantitative determination of different molecular species is not trivial as many parameters seriously affect the outcome of any experiment. In this work, we use as a case study the quantitative analysis of ionic organics dyes. We report on the role of different molecular properties to the modulation of the surface‐enhanced Raman scattering signal, the useful dynamic range for the determination, the dynamics of the molecule‐nanoparticle interaction process, and the time dependency of the signal. The consequences on the quantitative determination on dye mixtures, often found in the analysis of artworks, are discussed.