It is recognized that total testosterone (TT) does not sufficiently describe androgen status when sex hormone-binding globulin (SHBG) is altered. However, in humans, evidence supporting the existence of a hypogonadism due to low T bioactivity is scanty. The aim of the study was to assess whether changes in SHBG levels, independently of TT, are associated with subjective and objective androgen-dependent parameters.
Sex hormone-binding globulin is associated with androgen deficiency features independently of total testosterone / Rastrelli, Giulia; Corona, Giovanni; Cipriani, Sarah; Mannucci, Edoardo; Maggi, Mario. - In: CLINICAL ENDOCRINOLOGY. - ISSN 0300-0664. - STAMPA. - 88:(2018), pp. 556-564. [10.1111/cen.13530]
Sex hormone-binding globulin is associated with androgen deficiency features independently of total testosterone
Rastrelli, Giulia;Corona, Giovanni;Cipriani, Sarah;Mannucci, Edoardo;Maggi, Mario
2018
Abstract
It is recognized that total testosterone (TT) does not sufficiently describe androgen status when sex hormone-binding globulin (SHBG) is altered. However, in humans, evidence supporting the existence of a hypogonadism due to low T bioactivity is scanty. The aim of the study was to assess whether changes in SHBG levels, independently of TT, are associated with subjective and objective androgen-dependent parameters.
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