Combined therapies with nanostructured carbon materials: there is room still available at the bottom

The progress of the chemistry of carbon nanotubes (CNT) and graphene derivatives [mainly graphene oxide (GO)] has produced a number of technologically advanced drug delivery systems (DDS) that have been used in the field of nanomedicine, mostly in studies related to oncology. However, such a demanding field of research requires continuous improvements in terms of efficiency, selectivity and versatility. The loading of two, or more, bioactive component on the same nanoparticle offers new possibilities for treating cancer, efficiently addressing the different issues related to bioavailability and pharmacokinetics. Nanostructured Carbon Materials (NCM), with their high surface area, their efficient cellular membrane crossing and their chemical versatility are ideal candidate for this approach. This review describes the achievements obtained in this area focusing on those studies in which two, or more, active components were loaded onto the DDS.