To determine whether exosomal microRNAs (miRNAs) in cerebrospinal fluid (CSF) of patients with frontotemporal dementia (FTD) can serve as diagnostic biomarkers, we assessed miRNA expression in the Genetic Frontotemporal Dementia Initiative (GENFI) cohort and in sporadic FTD. In the GENFI cohort, miR-204-5p and miR-632 were significantly decreased in symptomatic compared with presymptomatic mutation carriers. Decrease of miR-204-5p and miR-632 revealed receiver operator characteristics with an area of 0.89 (90% CI 0.79 to 0.98) and 0.81 (90% CI 0.68 to 0.93), respectively, and when combined an area of 0.93 (90% CI 0.87 to 0.99). In sporadic FTD, only miR-632 was significantly decreased compared with AD and HCs. Decrease of miR-632 revealed an area of 0.90 (90% CI 0.81 to 0.98). Exosomal miR-204-5p and miR-632 have potential as diagnostic biomarkers for genetic FTD and miR-632 also for sporadic FTD.
Downregulation of exosomal miR-204-5p and miR-632 as a biomarker for FTD: a GENFI study / Schneider, Raphael; McKeever, Paul; Kim, TaeHyung; Graff, Caroline; van Swieten, John Cornelis; Karydas, Anna; Boxer, Adam; Rosen, Howie; Miller, Bruce L; Laforce, Robert; Galimberti, Daniela; Masellis, Mario; Borroni, Barbara; Zhang, Zhaolei; Zinman, Lorne; Rohrer, Jonathan Daniel; Andersson, C; Archetti, S; Arighi, A; Benussi, L; Binetti, G; Black, S; Bocchetta, M; Cash, D; Cosseddu, M; Dick, K; Fallström, M; Ferreira, C; Fenoglio, C; Fox, N; Freedman, M; Frisoni, G; Fumagalli, G; Gazzina, S; Ghidoni, R; Grisoli, M; Jelic, V; Jiskoot, L; Keren, R; Lombardi, G; Maruta, C; Meeter, L; Rick van Minkelen, MA; Nacmias, B; Öijerstedt, L; Ourselin, S; Padovani, A; Panman, J; Pievani, M; Polito, C; Premi, E; Prioni, S; Rademakers, R; Redaelli, V; Rogaeva, E; Rossi, G; Rossor, M; Row, J; Scarpini, E; Tagliavini, F; Sorbi, S; Tang-Wai, D; Thomas, D; Thonberg, H; Tiraboschi, P; Verdelho, A; Warren, J; Tartaglia, Maria Carmela; Robertson, Janice;. - In: JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY. - ISSN 0022-3050. - ELETTRONICO. - jnnp-2017-317492:(2018), pp. 0-0. [10.1136/jnnp-2017-317492]
Downregulation of exosomal miR-204-5p and miR-632 as a biomarker for FTD: a GENFI study
Ferreira, C;FUMAGALLI, GIORGIO GIULIO;Lombardi, G;Nacmias, B;Polito, C;Sorbi, S;
2018
Abstract
To determine whether exosomal microRNAs (miRNAs) in cerebrospinal fluid (CSF) of patients with frontotemporal dementia (FTD) can serve as diagnostic biomarkers, we assessed miRNA expression in the Genetic Frontotemporal Dementia Initiative (GENFI) cohort and in sporadic FTD. In the GENFI cohort, miR-204-5p and miR-632 were significantly decreased in symptomatic compared with presymptomatic mutation carriers. Decrease of miR-204-5p and miR-632 revealed receiver operator characteristics with an area of 0.89 (90% CI 0.79 to 0.98) and 0.81 (90% CI 0.68 to 0.93), respectively, and when combined an area of 0.93 (90% CI 0.87 to 0.99). In sporadic FTD, only miR-632 was significantly decreased compared with AD and HCs. Decrease of miR-632 revealed an area of 0.90 (90% CI 0.81 to 0.98). Exosomal miR-204-5p and miR-632 have potential as diagnostic biomarkers for genetic FTD and miR-632 also for sporadic FTD.
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